HDGF - heparin binding growth factor Gene

Also Known as HMG1L2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3068

About HDGF

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,742,107-156,767,366 (from NCBI)

This gene has 10 transcripts (splice variants), 188 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 90.4), liver (RPKM 48.1) and 25 other tissues.

Summary

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

HDGF Products (6)

mRNA Protein Name
NM_001126050.2 NP_001119522.1 hepatoma-derived growth factor isoform b
NM_001126051.1 NP_001119523.1 hepatoma-derived growth factor isoform c
NM_001319186.2 NP_001306115.1 hepatoma-derived growth factor isoform d
NM_001319187.2 NP_001306116.1 hepatoma-derived growth factor isoform e
NM_001319188.2 NP_001306117.1 hepatoma-derived growth factor isoform e
NM_004494.3 NP_004485.1 hepatoma-derived growth factor isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
26845719 GOA
NOT enables heparin binding IDA
IDA: Inferred from direct assay
26845719 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
26845719 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26845719 GOA
enables transcription corepressor activity IDA
IDA: Inferred from direct assay
19162039 GOA
enables transcription corepressor binding IPI
IPI: Inferred from physical interaction
19162039 GOA
enables tubulin binding IDA
IDA: Inferred from direct assay
26845719 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
19162039 GOA
NOT involved in positive regulation of cell division IDA
IDA: Inferred from direct assay
26845719 GOA
involved in positive regulation of cell division IDA
IDA: Inferred from direct assay
26845719 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26845719 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
27926477 GOA
located in nucleus IDA
IDA: Inferred from direct assay
26845719 GOA
part of transcription repressor complex IDA
IDA: Inferred from direct assay
19162039 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HDGF Protein Structure

PWWP

PWWP: PWWP domain (10 - 90)

  • 0
  • 100
  • 200
  • 240 a.a.
Protein Preferred Names Protein Names

hepatoma-derived growth factor

  • epididymis secretory sperm binding protein

Recombinant HDGF Proteins

Cat. No. Product Name Accession Purity
HY-P70368 HDGF Protein, Human (His) P51858-1 (M1-Y100) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700087AF Animal-Free HDGF Protein, Human (His) P51858-1 (M1-L240) ≥ 95%, as determined by reducing SDS-PAGE.

HDGF Antibodies

Cat. No. Product Name Application Reactivity
HY-P86898 HDGF Antibody (YA6591) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06094 HDGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17289 Hdgf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23744 Hdgf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus HDGF RGD RGD:70961
Canis familiaris HDGF VGNC VGNC:41627
Mus musculus HDGF MGD MGI:1194494
Felis catus HDGF VGNC VGNC:103733
Macaca mulatta HDGF VGNC VGNC:99967
Bos taurus HDGF VGNC VGNC:29787
Others HDGF NCBI