HDGF Protein, Human (His)
The HDGF protein acts as a transcriptional repressor and was previously thought to have mitogenic activity for fibroblasts and be a heparin-binding protein. However, recent studies have shown that it does not exhibit mitogenic activity for fibroblasts and does not bind heparin. HDGF Protein, Human (His) is the recombinant human-derived HDGF protein, expressed by E. coli , with C-6*His labeled tag.
- Species: Human
- Source: E. coli
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Biological Activity
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Product Properties
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Biological Activity
The HDGF protein acts as a transcriptional repressor and was previously thought to have mitogenic activity for fibroblasts and be a heparin-binding protein. However, recent studies have shown that it does not exhibit mitogenic activity for fibroblasts and does not bind heparin. HDGF Protein, Human (His) is the recombinant human-derived HDGF protein, expressed by E. coli , with C-6*His labeled tag.
Hepatoma-derived growth factor (HDGF) exhibits a dual role as both a transcriptional repressor and a mitogenic factor for fibroblasts. While it acts as a repressor in transcriptional regulation, influencing cellular processes, it also demonstrates mitogenic activity, particularly for fibroblasts. HDGF has been identified as a heparin-binding protein, which suggests its involvement in interactions with heparin and potentially modulating cellular responses. However, it's noteworthy that conflicting reports exist, with some studies indicating that HDGF lacks mitogenic activity for fibroblasts and does not bind to heparin. These findings highlight the complexity of HDGF's functional repertoire, showcasing its diverse roles in transcriptional control, mitogenic signaling, and potential interactions with heparin.
Technical Parameters
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Species Human
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Source E. coli
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Tag C-6*His
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Accession
P51858-1 (M1-Y100)
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Molecular Construction
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N-term
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HDGF (M1-Y100)
Accession # P51858-1 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
HDGF; Hepatoma-Derived Growth Factor; Heparin Binding Growth Factor; Hepatoma-Derived Growth Factor (High-Mobility Group Protein 1-Like); HMG1L2; High-Mobility Group Protein 1-Like; Epididymis Secretory Sperm Binding Protein; Hepatoma-Derived Growth Facto
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AA Sequence
MSRSNRQKEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLWEIENNPTVKASGY
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Predicted Molecular Mass
12.6 kDa
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Molecular Weight
Approximately 14 kDa, based on SDS-PAGE under reducing conditions.
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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