2. GPCR/G Protein
  3. GCGR
  4. [Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes.

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[Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon Estructura química

No. CAS : 110121-11-4

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[Des-His1,Glu9] Glucagon Related Antibodies

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Descripciòn

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes[1].

IC50 & Target

Glucagon Receptor[1]
In Vitro

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

[Des-His1,Glu9] Glucagon Related Antibodies
In Vivo

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)[1]
Dosage: 3.6-4.0 μg/kg
Administration: i.v.; single dosage
Result: Suppressed hyperglycemic response of glucagon.
Animal Model: Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)][1]
Dosage: 1 mg/kg
Administration: Intravenously administration through the tail vein; single dosage
Result: Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.
Peso molecular

3359.63

Fòrmula

C148H220N40O48S
No. CAS
Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT
Envío

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Almacenamiento

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Pureza y Documentación
Referencias
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[Des-His1,Glu9] Glucagon Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

[Des-His1,Glu9] Glucagon110121-11-4GCGRGlucagon Receptorglucagondiabeteshyperglycemiablood glucoseInhibitorinhibitorinhibit

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Nombre del producto:
[Des-His1,Glu9] Glucagon
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HY-P3608
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