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Cat. No.: HY-P3608

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[Des-His1,Glu9] Glucagon

[Des-His1,Glu9] Glucagon is a potent glucagon receptor system peptide antagonist. [Des-His1,Glu9] Glucagon enhances the glucose-stimulated release of insulin from pancreatic islet cells. [Des-His1,Glu9] Glucagon can be used to research diabetes.

For research use only. We do not sell to patients.

CAS No.: 110121-11-4
Formula: C₁₄₈H₂₂₀N₄₀O₄₈S
Molecular Weight:3359.63

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

[Des-His1,Glu9] Glucagon Chemical Structure

CAS No.: 110121-11-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

Glucagon Receptor^[1]

In Vitro

[Des-His1,Glu9] Glucagon (1 pM-100 μM) does not activate membrane-bound adenylate cyclase up to a concentration of 2×10^-4 molar in the cAMP assay on isolated rat liver membranes (from male Sprague Dawley rats)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

[Des-His1,Glu9] Glucagon (3.6-4.0 μg/kg for rabbits, 1 mg/kg for rats; i.v.; single dosage) suppresses hyperglycemic effects in rabbits and rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

New Zealand rabbits (2.8-3.8 kg; fasted for 18 hours)^[1]
Dosage:

3.6-4.0 μg/kg
Administration:

i.v.; single dosage
Result:

Suppressed hyperglycemic response of glucagon.

Animal Model:

Male Wistar rats weighing [350-400 mg; hyperglycemia induced by i.p. injection of 65 mg/kg Streptozotocin (HY-13753)]^[1]
Dosage:

1 mg/kg
Administration:

Intravenously administration through the tail vein; single dosage
Result:

Decreased blood glucose rapidly, and reduced hyperglycemic effect by 70% within 5 min.

Chemical Information

CAS No. 110121-11-4
Molecular Weight 3359.63
Formula C₁₄₈H₂₂₀N₄₀O₄₈S
Sequence Shortening

SQGTFTSEYSKYLDSRRAQDFVQWLMNT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Unson CG, et al. Biological activities of des-His1[Glu9]glucagon amide, a glucagon antagonist. Peptides. 1989 Nov-Dec;10(6):1171-7. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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