2. Disease Areas
  3. Infection Urogenital Disease
  4. HIV Infection Sexually Transmitted Disease
  5. HIV-2 Infection

HIV-2 Infection

HIV-2 infection is a distinct form of human immunodeficiency virus infection primarily found in West Africa, caused by a virus with a longer incubation period than HIV-1 and associated with AIDS. It originated from zoonotic transmission of simian immunodeficiency virus from sooty mangabeys, resulting in eight viral groups, only A and B of which have sustained human-to-human spread. HIV-2 infection is characterized by robust cellular immune responses targeting conserved Gag epitopes, early differentiation of highly polyfunctional CD8+ T cells with high functional avidity, and support from polyfunctional CD4+ T cells, all occurring amid significantly lower immune activation compared to HIV-1. Notably, HIV-2 exhibits slower viral evolution and reduced adaptive immune escape in asymptomatic individuals, distinguishing it from HIV-1.

HIV-2 Infection (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-182474
    INDOPY-1 352548-47-1
    INDOPY-1 (Indolopyridone-1) is a selective, reversible, and competitive HIV-1 reverse transcriptase inhibitor. INDOPY-1 reversibly binds to the active site of reverse transcriptase. INDOPY-1 inhibits DNA synthesis. INDOPY-1 exhibits antiviral activity against various retroviruses, including HIV-1 IIIB, HIV-1 HXB2 K103N Y181C, HIV-2 ROD, and SIV Mac251. INDOPY-1 can be used in the research of immunodeficiency virus infection.
    INDOPY-1