Aldh3a1 - aldehyde dehydrogenase family 3, subfamily A1 Gene

Also Known as Ahd4; Aldh; Ahd-4; Aldh3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 11670

About Aldh3a1

Chromosome 11: 61,098,363-61,109,247 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 370 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue.

Summary

Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh3a1 Products (3)

mRNA Protein Name
NM_007436.2 NP_031462.2 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001112725.1 NP_001106196.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001331112.1 NP_001318041.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 2

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: Inferred from direct assay
742739 MGI
enables 3-chloroallyl aldehyde dehydrogenase activity IMP
IMP: Inferred from mutant phenotype
11784860 MGI
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: Inferred from direct assay
25286108 MGI
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
IDA: Inferred from direct assay
10376761 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
25286108 MGI
located in membrane IDA
IDA: Inferred from direct assay
25286108 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Aldh3a1 Protein Structure

ALDH_F3AB

ALDH_F3AB: cd07132 (4 - 446)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
Protein Preferred Names Protein Names

aldehyde dehydrogenase, dimeric NADP-preferring

  • alcohol dehydrogenase family 3, subfamily A1

  • aldehyde dehydrogenase 3, stomach cytosolic (class 3)

  • aldehyde dehydrogenase 4

  • aldehyde dehydrogenase family 3 member A1

  • dioxin-inducible aldehyde dehydrogenase 3

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0364A Dyclonine hydrochloride 99.12% Unkown

Pre-clinical Phase

Bioactive Molecules (21)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123962 G6PD activator AG1 99.54% Unkown
HY-125085 ALDH3A1-IN-3 Inhibitor 99.43% Unkown
HY-144670 ALDH3A1-IN-1 Inhibitor 99.85% Unkown
HY-W017186 ALDH1A3-IN-3 Inhibitor 99.26% Unkown
HY-122577 EN40 Inhibitor 99.33% Unkown
HY-144669 ALDH1A3-IN-2 Inhibitor 99.85% Unkown
HY-146683 KS106 99.87% Unkown
HY-146682 KS100 99.61% Unkown
HY-RS00571 ALDH3A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-128299 ALDH3A1-IN-4 Inhibitor 99.91% Unkown
HY-134917 Aldi-2 Inhibitor / Unkown
HY-144671 ALDH3A1-IN-2 Inhibitor / Unkown
HY-159111 KS124 / Unkown
HY-184776 Dyclonine / Unkown
HY-B0364AS Dyclonine-d9 hydrochloride / Unkown
HY-D3442 ALDH2 probe 5 Ligand / Unkown
HY-RS00572 Aldh3a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00573 Aldh3a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21982 Aldh3b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28499 Aldh3b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Aldh3a1 NCBI NCBI:218