2. Metabolic Enzyme/Protease
  3. Aldehyde Dehydrogenase (ALDH)
  4. EN40

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM

For research use only. We do not sell to patients.

EN40 Chemical Structure

EN40 Chemical Structure

CAS No. : 2094547-67-6

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5 mg USD 450 In-stock
10 mg USD 750 In-stock
25 mg USD 1350 In-stock
50 mg USD 2250 In-stock
100 mg USD 3350 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]

IC50 & Target

IC50: 2 uM (ALDH3A1)[1]
In Vitro

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

EN40 Related Antibodies

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 10 μM; 100 μM; 1000 μM
Incubation Time: 48 hours
Result: Inhibited A549 cells survival.
In Vivo

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with A549 cells[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day
Result: Had strong anti-tumorigenic effects in tumor xenografts.
Molecular Weight

217.26

Formula

C13H15NO2
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

Ethanol : 100 mg/mL (460.28 mM; Need ultrasonic)

DMSO : ≥ 100 mg/mL (460.28 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6028 mL 23.0139 mL 46.0278 mL
5 mM 0.9206 mL 4.6028 mL 9.2056 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.56%

COA (248 KB) HNMR (140 KB) RP-HPLC (233 KB) LCMS (241 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 4.6028 mL 23.0139 mL 46.0278 mL 115.0695 mL
5 mM 0.9206 mL 4.6028 mL 9.2056 mL 23.0139 mL
10 mM 0.4603 mL 2.3014 mL 4.6028 mL 11.5070 mL
15 mM 0.3069 mL 1.5343 mL 3.0685 mL 7.6713 mL
20 mM 0.2301 mL 1.1507 mL 2.3014 mL 5.7535 mL
25 mM 0.1841 mL 0.9206 mL 1.8411 mL 4.6028 mL
30 mM 0.1534 mL 0.7671 mL 1.5343 mL 3.8357 mL
40 mM 0.1151 mL 0.5753 mL 1.1507 mL 2.8767 mL
50 mM 0.0921 mL 0.4603 mL 0.9206 mL 2.3014 mL
60 mM 0.0767 mL 0.3836 mL 0.7671 mL 1.9178 mL
80 mM 0.0575 mL 0.2877 mL 0.5753 mL 1.4384 mL
100 mM 0.0460 mL 0.2301 mL 0.4603 mL 1.1507 mL
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EN40 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

EN402094547-67-6EN 40EN-40Aldehyde Dehydrogenase (ALDH)lungtumorcancerALDHInhibitorinhibitorinhibit

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