1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. EN40

EN40 

Cat. No.: HY-122577 Purity: 95.15%
Handling Instructions

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM

For research use only. We do not sell to patients.

EN40 Chemical Structure

EN40 Chemical Structure

CAS No. : 2094547-67-6

Size Price Stock Quantity
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1350 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
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100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]

IC50 & Target

IC50: 2 uM (ALDH3A1)[1]

In Vitro

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 10 μM; 100 μM; 1000 μM
Incubation Time: 48 hours
Result: Inhibited A549 cells survival.
In Vivo

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1].

Animal Model: SCID mice with A549 cells[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day
Result: Had strong anti-tumorigenic effects in tumor xenografts.
Molecular Weight

217.26

Formula

C₁₃H₁₅NO₂

CAS No.

2094547-67-6

SMILES

C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (23.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6028 mL 23.0139 mL 46.0278 mL
5 mM 0.9206 mL 4.6028 mL 9.2056 mL
10 mM 0.4603 mL 2.3014 mL 4.6028 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

EN40EN 40EN-40Aldehyde Dehydrogenase (ALDH)lungtumorcancerALDHInhibitorinhibitorinhibit

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EN40
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HY-122577
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