1. Metabolic Enzyme/Protease
  2. Aldehyde Dehydrogenase (ALDH)
  3. EN40

EN40 

Cat. No.: HY-122577
Handling Instructions

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM

For research use only. We do not sell to patients.

EN40 Chemical Structure

EN40 Chemical Structure

CAS No. : 2094547-67-6

Size Price Stock
10 mM * 1 mL in DMSO USD 359 Ask For Quote & Lead Time
5 mg USD 450 Ask For Quote & Lead Time
10 mg USD 750 Ask For Quote & Lead Time
25 mg USD 1350 Ask For Quote & Lead Time
50 mg USD 2250 Ask For Quote & Lead Time
100 mg USD 3350 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1]

IC50 & Target

IC50: 2 uM (ALDH3A1)[1]

In Vitro

EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1].

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 10 μM; 100 μM; 1000 μM
Incubation Time: 48 hours
Result: Inhibited A549 cells survival.
In Vivo

EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1].

Animal Model: SCID mice with A549 cells[1]
Dosage: 50 mg/kg
Administration: Intraperitoneal injection; 50mg/kg; from 14 days; once per day
Result: Had strong anti-tumorigenic effects in tumor xenografts.
Molecular Weight

217.26

Formula

C₁₃H₁₅NO₂

CAS No.

2094547-67-6

SMILES

C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

EN40EN 40EN-40Aldehyde Dehydrogenase (ALDH)lungtumorcancerALDHInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
EN40
Cat. No.:
HY-122577
Quantity:
MCE Japan Authorized Agent: