ALDH3A1-IN-2
ALDH3A1-IN-2 (Compound 19) is a potent inhibitor of ALDH3A1 with an IC50 of 1.29 μM. Aldehyde dehydrogenases (ALDHs) are overexpressed in various tumor types including prostate cancer. ALDH3A1-IN-2 has the potential for the research of cancer diseases.
For research use only. We do not sell to patients.
- CAS No.: 374635-48-0
- Formula: C11H14N2O3
- Molecular Weight:222.24
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
ALDH3 |
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
>200 μM
Compound: 19
|
Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human DU145 cells expressing ALDH1A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
|
[PMID: 35212533] |
| LNCaP | IC50 |
136 μM
Compound: 19
|
Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human LNCaP cells expressing ALDH1A3 assessed as reduction in cell survival measured after 96 hrs by MTT assay
|
[PMID: 35212533] |
| PC-3 | IC50 |
>200 μM
Compound: 19
|
Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
Antiproliferative activity against human PC-3 cells expressing ALDH1A1 and ALDH3A1 assessed as reduction in cell survival measured after 96 hrs by MTT assay
|
[PMID: 35212533] |
Chemical Information
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CAS No. 374635-48-0
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Molecular Weight 222.24
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Formula C11H14N2O3
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SMILES
O=CC1=CC([N+]([O-])=O)=C(C=C1)N(CC)CC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)