NUDT9 - nudix hydrolase 9 Gene

Also Known as NUDT10

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 53343

About NUDT9

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,422,573-87,459,455 (from NCBI)

This gene has 8 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in kidney (RPKM 6.8), prostate (RPKM 6.3) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the Nudix hydrolase family. Nudix boxes are found in a family of diverse Enzymes that catalyze the hydrolysis of nucleoside diphosphate derivatives. This enzyme is an ADP-ribose pyrophosphatase that catalyzes the hydrolysis of ADP-ribose to AMP and ribose-5-P. It requires divalent metal ions and an intact Nudix motif for enzymatic activity. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

NUDT9 Products (3)

mRNA Protein Name
NM_001248011.2 NP_001234940.1 ADP-ribose pyrophosphatase, mitochondrial isoform c precursor
NM_024047.5 NP_076952.1 ADP-ribose pyrophosphatase, mitochondrial isoform a precursor
NM_198038.3 NP_932155.1 ADP-ribose pyrophosphatase, mitochondrial isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ADP-ribose diphosphatase activity EXP
EXP: Inferred from Experiment
12948489 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUDT9 Protein Structure

NUDIX

NUDIX: NUDIX domain (198 - 325)

  • 0
  • 100
  • 200
  • 300
  • 350 a.a.
Protein Preferred Names Protein Names

ADP-ribose pyrophosphatase, mitochondrial

  • ADP-ribose diphosphatase

NUDT9 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81708 NUDT9 Antibody (YA1453) WB, ICC/IF Human, Rat
HY-P81708A NUDT9 Antibody (YA1453)(PBS only) WB, ICC/IF Human, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-125209A TH5427 hydrochloride / Unkown
HY-RS09675 NUDT9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-134268 8-Br-7-CH-ADPR Antagonist / Unkown
HY-181481 2'-Deoxyadenosine-5'-O-diphosphoribose sodium Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NUDT9 VGNC VGNC:75555
Bos taurus NUDT9 VGNC VGNC:32343
Rattus norvegicus NUDT9 RGD RGD:1359522
Canis familiaris NUDT9 VGNC VGNC:44037
Felis catus NUDT9 VGNC VGNC:78541
Mus musculus NUDT9 MGD MGI:1921417
Others NUDT9 NCBI