DPPE-PEG2000-VHPKQHRGGSKGC

DPPE-PEG2000-VHPKQHRGGSKGC is composed of three covalently linked components: 1. DPPE (1,2-dipalmitoyl-sn-glycerol-3-phosphate ethanolamine): Lipid anchoring group-inserts into the lipid bilayer of liposomes/LNPs, providing stable membrane anchoring; its saturated C16 chain imparts bilayer rigidity. 2. PEG 2000 (polyethylene glycol, molecular weight 2000): Hydrophilic polymer spacer arm-forms a steric hindrance crown around the nanoparticles, reducing opsonin activity and reticuloendothelial system (RES) clearance, prolonging circulating half-life, and providing spatial separation between the lipid surface and the targeting ligand. 3. VHPKQHRGGSKGC peptide: Targeting/functional ligand-the VHPKQHRGGSKGC peptide specifically binds to vascular cell adhesion molecule 1 (VCAM-1), which is highly expressed on the surface of inflammatory-activated endothelial cells and tumor vessels, achieving inflammation/tumor vascular targeting.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.