2. Anti-infection
  3. Virus Protease
  4. Encephalitic alphavirus-IN-1

Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity.

For research use only. We do not sell to patients.

Encephalitic alphavirus-IN-1

Encephalitic alphavirus-IN-1 Chemical Structure

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Encephalitic alphavirus-IN-1 Related Antibodies

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Description

Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity[1].

IC50 & Target

EC50: 0.24 μM (VEEV), 0.16 μM (EEEV)[1]
Cellular Effect
Cell Line Type Value Description References
Vero 76 CC50
23.3 μM
Compound: 7o
Cytotoxicity against African green monkey Vero 76 assessed as reduction in cell viability measured after 72 hrs
Cytotoxicity against African green monkey Vero 76 assessed as reduction in cell viability measured after 72 hrs
[PMID: 35450382]
Vero 76 EC50
0.16 μM
Compound: 7o
Antiviral activity against eastern equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
Antiviral activity against eastern equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
[PMID: 35450382]
Vero 76 EC50
0.24 μM
Compound: 7o
Antiviral activity against Venezuelan equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
Antiviral activity against Venezuelan equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
[PMID: 35450382]
In Vitro

Encephalitic alphavirus-IN-1 (1 and 5 μM; 18 hours) reduces substantial VEEV and EEEV in human brain primary neuronal cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Encephalitic alphavirus-IN-1 Related Antibodies
Molecular Weight

484.52

Formula

C27H25FN6O2
SMILES

[H]C12C(N(CCN2C)C)=NC3=C(C=C(C=C3C(N1C4=CC(F)=C(C=C4)OC)=O)C#N)C5=CC=C(N=C5)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Encephalitic alphavirus-IN-1 Related Classifications

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  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Encephalitic alphavirus-IN-1Virus ProteaseVenezuelan equine encephalitis virusEastern equine encephalitis virusesAntiviral activityHNC001Neuronal cellsInhibitorinhibitorinhibit

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Encephalitic alphavirus-IN-1
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