Encephalitic alphavirus-IN-1
Encephalitic alphavirus-IN-1 has antiviral activity for VEEV and EEEV with EC50s of 0.24 μM and 0.16 μM, respectively. Encephalitic alphavirus-IN-1 has robust mouse plasma stability, and no obvious cytotoxicity.
For research use only. We do not sell to patients.
- Formula: C27H25FN6O2
- Molecular Weight:484.52
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 0.24 μM (VEEV), 0.16 μM (EEEV)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero 76 | CC50 |
23.3 μM
Compound: 7o
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Cytotoxicity against African green monkey Vero 76 assessed as reduction in cell viability measured after 72 hrs
Cytotoxicity against African green monkey Vero 76 assessed as reduction in cell viability measured after 72 hrs
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[PMID: 35450382] |
| Vero 76 | EC50 |
0.16 μM
Compound: 7o
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Antiviral activity against eastern equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
Antiviral activity against eastern equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
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[PMID: 35450382] |
| Vero 76 | EC50 |
0.24 μM
Compound: 7o
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Antiviral activity against Venezuelan equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
Antiviral activity against Venezuelan equine encephalitis virus infected in African green monkey Vero 76 cells assessed as virus induced cytopathic effect measured after 48 hrs
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[PMID: 35450382] |
Encephalitic alphavirus-IN-1 (1 and 5 μM; 18 hours) reduces substantial VEEV and EEEV in human brain primary neuronal cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 484.52
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Formula C27H25FN6O2
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SMILES
[H]C12C(N(CCN2C)C)=NC3=C(C=C(C=C3C(N1C4=CC(F)=C(C=C4)OC)=O)C#N)C5=CC=C(N=C5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Encephalitic alphavirus-IN-1 Related Classifications
HY-145842 Related Classifications
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