ZG-126
ZG-126 is an agonist for vitamin D receptor (VDR) and an inhibitor for histone deacetylase (HDAC) (IC50=0.63-67.6 μM). ZG-126 exhibits cytotoxicity in cancer cells MDA-MB-231 and 4T1. ZG-126 exhibits antitumor and anti-metastatic efficacy against melanoma and triple-negative breast cancer (TNBC) in mouse models. ZG-126 also exhibits anti-inflammatory activity, through the reduction of macrophage infiltration and immunosuppressive M2-polarization.
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- No. CAS: 3049802-32-3
- Fòrmula: C29H43N3O5
- Peso molecular:513.67
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
|
HDAC6 0.633 μM (IC50) |
HDAC3 0.997 μM (IC50) |
HDAC11 2.02 μM (IC50) |
HDAC1 2.53 μM (IC50) |
HDAC8 3.31 μM (IC50) |
HDAC2 4.64 μM (IC50) |
HDAC10 13.9 μM (IC50) |
HDAC7 55.4 μM (IC50) |
HDAC5 59.4 μM (IC50) |
HDAC4 67.6 μM (IC50) |
Chemical Information
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No. CAS 3049802-32-3
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Peso molecular 513.67
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Fòrmula C29H43N3O5
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SMILES
CCC(CC)(C1=CC=C(C=C1)C(NCCCCC(NO)=O)=O)C2=NC(C)=C(C=C2)OCC(C(C)(C)C)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ZG-126 Related Classifications
HY-161778 Related Classifications
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