2. Protein Tyrosine Kinase/RTK
  3. FAK
  4. FAK-IN-17

FAK-IN-17 is a focal adhesion kinase (FAK) inhibitor. FAK-IN-17 possesses anticancer activity against A549 and MDA-MB-231 cell lines with IC50 values of 130 nM and 94 nM.

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FAK-IN-17

FAK-IN-17 Chemische Struktur

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FAK-IN-17 Related Antibodies

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Beschreibung

FAK-IN-17 is a focal adhesion kinase (FAK) inhibitor. FAK-IN-17 possesses anticancer activity against A549 and MDA-MB-231 cell lines with IC50 values of 130 nM and 94 nM[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
0.13 μM
Compound: A12
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37974962]
MDA-MB-231 IC50
0.094 μM
Compound: A12
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell proliferation incubated for 72 hrs by MTT assay
[PMID: 37974962]
Molekulargewicht

499.93

Formel

C24H27ClN5O3P
SMILES

ClC1=CN=C(NC2=CC=C(C(NC3CCOCC3)=O)C=C2)N=C1NC4=CC=CC=C4P(C)(C)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

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Verweise
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FAK-IN-17 Related Classifications

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)

Diese Gleichung wird häufig abgekürzt als: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FAK-IN-17FAKPTK2 protein tyrosine kinase 2PTK2Focal adhesion kinaseanticnacerA549NSCLCbreast cancerlung cancerMDA-MB-231Inhibitorinhibitorinhibit

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