Fmoc-NH-PEG11-CH2CH2COOH

Cat. No.: HY-130870 Purity: 99.73%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

Fmoc-NH-PEG11-CH2CH2COOH Chemical Structure

Size	Price	Stock	Quantity
25 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 95	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Biological Activity
Purity & Documentation
References
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Description

Fmoc-NH-PEG11-CH2CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

795.91

Formula

C₄₀H₆₁NO₁₅

Appearance

Viscous Liquid

Color

Colorless to light yellow

SMILES

O=C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCC(O)=O)OCC1C(C=CC=C2)=C2C3=C1C=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (125.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2564 mL	6.2821 mL	12.5642 mL
5 mM	0.2513 mL	1.2564 mL	2.5128 mL
10 mM	0.1256 mL	0.6282 mL	1.2564 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.73%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (247 KB) HNMR (300 KB) LCMS (260 KB)

Handling Instructions (2659 KB)

References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2564 mL	6.2821 mL	12.5642 mL	31.4106 mL
	5 mM	0.2513 mL	1.2564 mL	2.5128 mL	6.2821 mL
	10 mM	0.1256 mL	0.6282 mL	1.2564 mL	3.1411 mL
	15 mM	0.0838 mL	0.4188 mL	0.8376 mL	2.0940 mL
	20 mM	0.0628 mL	0.3141 mL	0.6282 mL	1.5705 mL
	25 mM	0.0503 mL	0.2513 mL	0.5026 mL	1.2564 mL
	30 mM	0.0419 mL	0.2094 mL	0.4188 mL	1.0470 mL
	40 mM	0.0314 mL	0.1571 mL	0.3141 mL	0.7853 mL
	50 mM	0.0251 mL	0.1256 mL	0.2513 mL	0.6282 mL
	60 mM	0.0209 mL	0.1047 mL	0.2094 mL	0.5235 mL
	80 mM	0.0157 mL	0.0785 mL	0.1571 mL	0.3926 mL
	100 mM	0.0126 mL	0.0628 mL	0.1256 mL	0.3141 mL