FmocNH-PEG3-CH2CH2NH2 hydrochloride

Name: FmocNH-PEG3-CH2CH2NH2 hydrochloride
Brand: MedChemExpress
SKU: HY-W190961
Rating: 4.5 (1 reviews)

Cat. No.: HY-W190961 Purity: 99.57%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

FmocNH-PEG3-CH2CH2NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.

For research use only. We do not sell to patients.

FmocNH-PEG3-CH2CH2NH2 hydrochloride Chemical Structure

CAS No. : 906079-91-2

Size	Price	Stock	Quantity
25 mg	USD 37	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

FmocNH-PEG3-CH2CH2NH2 (hydrochloride) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs^[1].

IC₅₀ & Target

PEGs

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

450.96

Formula

C₂₃H₃₁ClN₂O₅

CAS No.

906079-91-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(NCCOCCOCCOCCN)OCC1C2=C(C3=C1C=CC=C3)C=CC=C2.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (277.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 125 mg/mL (277.19 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2175 mL	11.0875 mL	22.1749 mL
5 mM	0.4435 mL	2.2175 mL	4.4350 mL
10 mM	0.2217 mL	1.1087 mL	2.2175 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.57%

Select Batch:

Data Sheet (268 KB) SDS (0 KB)

COA (245 KB) HNMR (282 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

References

[1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	2.2175 mL	11.0875 mL	22.1749 mL	55.4373 mL
	5 mM	0.4435 mL	2.2175 mL	4.4350 mL	11.0875 mL
	10 mM	0.2217 mL	1.1087 mL	2.2175 mL	5.5437 mL
	15 mM	0.1478 mL	0.7392 mL	1.4783 mL	3.6958 mL
	20 mM	0.1109 mL	0.5544 mL	1.1087 mL	2.7719 mL
	25 mM	0.0887 mL	0.4435 mL	0.8870 mL	2.2175 mL
	30 mM	0.0739 mL	0.3696 mL	0.7392 mL	1.8479 mL
	40 mM	0.0554 mL	0.2772 mL	0.5544 mL	1.3859 mL
	50 mM	0.0443 mL	0.2217 mL	0.4435 mL	1.1087 mL
	60 mM	0.0370 mL	0.1848 mL	0.3696 mL	0.9240 mL
	80 mM	0.0277 mL	0.1386 mL	0.2772 mL	0.6930 mL
	100 mM	0.0222 mL	0.1109 mL	0.2217 mL	0.5544 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.