JPS004
JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer.
(Pink: HDAC1-3 ligand (HY-50934); Blue: VHL ligand (HY-125845); Black: linker).
For research use only. We do not sell to patients.
- CAS No.: 2559747-12-3
- Formula: C47H61N7O6S
- Molecular Weight:852.10
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
|
VHL |
HDAC1 |
HDAC2 |
HDAC3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
4.3 μM
Compound: 1; JPS004
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
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[PMID: 35293758] |
JPS004 (10 μM, 24 h) efficiently degrades histone deacetylase 1, 2, and 3 and increases the acetylation levels of histone H3 at lysine 56 (H3K56ac) and histone H2B at lysine 5 (H2BK5ac) in HCT116 human colorectal cancer cells[1].
JPS004 (10 μM, 24 h) induces apoptosis but has no effect on the level of the anti-apoptotic protein cIAP2 in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2559747-12-3
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Molecular Weight 852.10
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Formula C47H61N7O6S
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SMILES
NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JPS004 Related Classifications
HY-176904 Related Classifications
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