Citicoline
Based on 4 publication(s) in Google Scholar
Citicoline is an endogenous intermediate in the synthesis of phosphatidylcholine which is a component of cell membranes. Citicoline inhibits reactive oxygen species (ROS) and apoptosis. Citicoline can be used for neurological disease and hearing loss study.
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- Pureza: 99.57%
- No. CAS: 987-78-0
- Fòrmula: C14H26N4O11P2
- Peso molecular:488.32
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years
* The compound is unstable in solutions, freshly prepared is recommended.
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Citicoline
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Citicoline (1-100 μM, 24 h or 24 h before glutamate treatment) increases rats retinal cells viability after glutamate-induced excitotoxicity, and has synergistic effects with Tramiprosate (Homotaurine) (HY-14602)[1].
Citicoline (100 μM, 24 h before glutamate treatment and 30 min before HG treatment) decreases proapoptotic effects associated with neuroretinal degeneration such as glutamate-induced excitotoxicity and high glucose (HG)-induced neurotoxicity, and has synergistic effects with Tramiprosate in rats retinal cells[1].
Citicoline (100 μM, 36-48 h) reduces apoptosis in mice cochlear hair cells (HCs) and HEI-OC-1 cells after Neomycin (HY-150520) exposure, decreases the mRNA level of pro-apoptotic factor and increases anti-apoptotic factor, suppresses proapoptotic protein expression[2][3].
Citicoline (100 μM, 36-48 h) attenuates oxidative stress in mice cochlear HCs and HEI-OC-1 cells after Neomycin injury[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Rat retinal cells
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Concentration:1, 10, 100 μM
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Incubation Time:24 h or 24 h before glutamate treatment (100 μM)
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Result:Did not affect viability of primary retinal cultures.
Significantly increased cell viability after glutamate-induced excitotoxicity, and had synergistic effects with homotaurine
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Cell Line:Rat retinal cells
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Concentration:100 μM
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Incubation Time:24 h before glutamate treatment and 30 min before HG treatment
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Result:Reduced apoptosis induced by administration of glutamate and HG, and had synergistic effects with homotaurine.
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Cell Line:HEI-OC-1, mice cochlear tissue
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Concentration:10 μM
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Incubation Time:36 or 48 h (pretreatment for 12 h and then treated with 10 mM neomycin together for 12 and 24 h in cochlear tissue and HEI-OC-1, respectively, then allowed to recover in culture medium for another 12
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Result:Showed significantly lower numbers of cleaved caspase 3-positive cells and TUNEL-positive cells than the neomycin-only group.
Significantly reduced the percentage of apoptosis.
The protein levels of cleaved caspase 3 were decreased compared with the Neomycin-only group.
Decreased the pro-apoptotic factor Bax, Casp3, Casp8, and Casp9, and increased anti-apoptotic factor Bcl-2 by qPT-PCR analysis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male C57Bl/6 mice (23-27 g) (The solution of convulsant pentylenetetrazole (1%) was infused intravenously at a flow rate of 0.01 ml/sec.)[2]
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Dosage:500, 1000 mg/kg
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Administration:Intraperitoneal injection (i.p.); 1 h before test
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Result:Increased the threshold of clonic seizures and tonic phase of seizures with lethal outcome in a dose of 500 mg/kg.
The anticonvulsant effect was most pronounced in a dose of 1000 mg/kg.
Chemical Information
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No. CAS 987-78-0
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Appearance Solid
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Peso molecular 488.32
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Fòrmula C14H26N4O11P2
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Color White to off-white
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SMILES
NC(C=CN1[C@H]2[C@H](O)[C@H](O)[C@@H](COP(OP(OCC[N+](C)(C)C)([O-])=O)(O)=O)O2)=NC1=O
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Synonyms
Cytidine diphosphate-choline; CDP-Choline; Cytidine 5'-diphosphocholine
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Structure Classification
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Initial Source
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years * The compound is unstable in solutions, freshly prepared is recommended.
Publications (4)
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Journal Impact Factor
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Most Recent
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Nat Neurosci
2023 Apr;26(4):542-554. PMID: 36941428
Citicoline purchased from MedChemExpress. Usage Cited in: Nat Neurosci. 2023 Apr;26(4):542-554. [Abstract]
In vivo EEG and ex vivo MEA recordings of KA epileptic mice treated with CDP-choline (Citicoline: 100 mg/kg) or vehicle control.
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Int J Biol Macromol
2025 Jan 5:139536. PMID: 39765299 -
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Solvente y solubilidad
H2O : 50 mg/mL (102.39 mM; Need ultrasonic)
DMSO : < 1 mg/mL (insoluble or slightly soluble)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
For the following dissolution methods, please prepare the working solution directly:
It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: PBS
Solubility: 50 mg/mL (102.39 mM); Clear solution; Need ultrasonic
Pureza y Documentación
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Ficha de datos (279 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Davinelli S, et al. Cytoprotective Effects of Citicoline and Homotaurine against Glutamate and High Glucose Neurotoxicity in Primary Cultured Retinal Cells. Oxid Med Cell Longev. 2017;2017:2825703. [Content Brief]
[2]. Karpova MN, et al. Increase of the seizure threshold in C57BL/6 mice after citicoline administration. Bull Exp Biol Med. 2015 Jan;158(3):315-7. [Content Brief]
[3]. Zhong Z, et al. Citicoline Protects Auditory Hair Cells Against Neomycin-Induced Damage. Front Cell Dev Biol. 2020 Aug 31;8:712. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| H2O | 1 mM | 2.0478 mL | 10.2392 mL | 20.4784 mL | 51.1959 mL |
| 5 mM | 0.4096 mL | 2.0478 mL | 4.0957 mL | 10.2392 mL | |
| 10 mM | 0.2048 mL | 1.0239 mL | 2.0478 mL | 5.1196 mL | |
| 15 mM | 0.1365 mL | 0.6826 mL | 1.3652 mL | 3.4131 mL | |
| 20 mM | 0.1024 mL | 0.5120 mL | 1.0239 mL | 2.5598 mL | |
| 25 mM | 0.0819 mL | 0.4096 mL | 0.8191 mL | 2.0478 mL | |
| 30 mM | 0.0683 mL | 0.3413 mL | 0.6826 mL | 1.7065 mL | |
| 40 mM | 0.0512 mL | 0.2560 mL | 0.5120 mL | 1.2799 mL | |
| 50 mM | 0.0410 mL | 0.2048 mL | 0.4096 mL | 1.0239 mL | |
| 60 mM | 0.0341 mL | 0.1707 mL | 0.3413 mL | 0.8533 mL | |
| 80 mM | 0.0256 mL | 0.1280 mL | 0.2560 mL | 0.6399 mL | |
| 100 mM | 0.0205 mL | 0.1024 mL | 0.2048 mL | 0.5120 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Citicoline Related Classifications
HY-B0739 Related Classifications
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