Referencia número: HY-100560

Abscisic acid

(Synonyms: (S)-(+)-Abscisic acid; ABA)

4 Cited Publications

Revisión del cliente

Based on 4 publication(s) in Google Scholar

Abscisic acid ((S)-(+)-Abscisic acid), an orally active phytohormone in fruits and vegetables, is an endogenously produced mammalian hormone. Abscisic acid is a growth inhibitor and can regulate many aspects of plant growth and development. Abscisic acid inhibits proton pump (H⁺-ATPase) and leads to the plasma membrane depolarization in a Ca²⁺-dependent manner. Abscisic acid, a LANCL2 natural ligand, is a potent insulin-sensitizing compound and has the potential for pre-diabetes, type 2 diabetes and metabolic syndrome.

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Pureza: 99.78%
No. CAS: 21293-29-8
Fòrmula: C₁₅H₂₀O₄
Peso molecular:264.32

Almacenamiento:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

Abscisic acid Chemical Structure

No. CAS: 21293-29-8

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
- Ensayo clínico
Chemical Information
Publications (4)
Solvente y solubilidad
- In Vitro
- In Vivo
Pureza y Documentación
Referencias
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Microbial Metabolite

LANCL2

Ver todos los productos específicos de isoformas ABA Receptor :

LANCL2

Ver todos los productos específicos de isoformas Endogenous Metabolite :

Cellular Effect

Cell Line	Type	Value	Description	References
N9	IC₅₀	68.02 μM Compound: 25	Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay Antineuroinflammatory activity in mouse N9 cells assessed as inhibition of LPS-induced nitric oxide production after 24 hrs by Griess assay	[PMID: 28073678]

In Vitro

In Arabidopsis cell cultures, Abscisic acid ((S)-(+)-Abscisic acid; 10 μM) simultaneously induces rapid alkalinization of the medium and plasma membrane depolarization^[1].
Abscisic acid (10 μM) increases Ca²⁺ in cytosol of Arabidopsis cell suspension. Abscisic acid does not inhibit proton pumping directly but through an increase in cytosolic Ca²⁺^[1].
Lanthionine synthetase C-like 2 (LANCL2) is the natural receptor for Abscisic acid. Abscisic acid, both at the organism levels and in specific muscle cells ex vivo, increases both glucose and fatty acid metabolism in the mitochondria, increases glycogen synthesis, activates PI3K independently of insulin and promotes GLUT4 translocation to the cell membrane^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Abscisic acid (orally; 0.125 μg/kg/day; for 12 weeks) improves glycemic control^[2].
Abscisic acid (orally; 0.125 μg/kg/day; for 12 weeks) results in significantly lower levels of TNF, MCP-1 and IL-6 in the DIO model. Abscisic acid increases metabolic activity in skeletal muscle^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Diet-induced obesity (DIO) mice at 4 weeks of age^[2]
Dosage:

0.125 µg/kg
Administration:

Orally; daily; for 12 weeks
Result:

Improved glycemic control in a diet-induced model of obesity

Ensayo clínico

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

No. CAS 21293-29-8
Appearance Solid
Peso molecular 264.32
Fòrmula C₁₅H₂₀O₄
Color White to off-white
SMILES

O=C(O)/C=C(C)\C=C\[C@@]1(O)C(C)=CC(CC1(C)C)=O
Synonyms

(S)-(+)-Abscisic acid; ABA
Structure Classification
- Terpenoids
- Sesquiterpenes
Initial Source
- Plants
- other families
- Animals
- Microorganisms
- Endogenous metabolite
Widespread
Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Nat Commun

Specific multivalent molecules boost CRISPR-mediated transcriptional activation. [Abstract]

2024 Aug 22;15(1):7222. PMID: 39174527

Abscisic acid purchased from MedChemExpress. Usage Cited in: Nat Commun. 2024 Aug 22;15(1):7222. [Abstract]

Relative mRNA expression of HBD and HBG1/2 in HEK293T cells expressing ABI1-mCherry-dCas9 fusion proteins targeted to the HS2 enhancer along with PYL1-BFP-dCpf1 fusion proteins targeted to the corresponding gene promoters. Cells were treated with and without abscisic acid (ABA: 100 μM).
Cell Genom

Synthetic rewriting of the IGH locus. [Abstract]

2026 Jun 10;6(6):101252. PMID: 42155442
Plants

Integrated Multi-Omics Analysis Revealed the Synergistic Regulatory Mechanisms of Salt Tolerance in Soybean (Kefeng 1). [Abstract]

2026 Feb 10;15(4):555. PMID: 41754262
ChemRxiv

2025 Apr 11.

Abscisic acid purchased from MedChemExpress. Usage Cited in: ChemRxiv. 2025 Apr 11.

The fluorescent imaging of Arabidopsis thaliana treated with various phytohormones (GAs: 1 μM, BR: 1 μg/mL, ABA (Abscisic acid): 1 μM, IAA: 0.1 μg/mL, Kinetin: 0.1 μg/mL, 383 Ethephon: 1 μg/mL) for 3 h prior to incubation with NFP-HDAC(10 μM).

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (378.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 1.25 mg/mL (4.73 mM; ultrasonic and warming and heat to 60°C)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.7833 mL

18.9165 mL

37.8329 mL

5 mM

0.7567 mL

3.7833 mL

7.5666 mL

10 mM

0.3783 mL

1.8916 mL

3.7833 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 5 mg/mL (18.92 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (275 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Mathias Brault, et al. Plasma membrane depolarization induced by abscisic acid in Arabidopsis suspension cells involves reduction of proton pumping in addition to anion channel activation, which are both Ca²⁺ dependent. Plant Physiol. 2004 May;135(1):231-43. [Content Brief]

[2]. Andrew Leber, et al. Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. Sci Rep. 2020 Jun 26;10(1):10463. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.7833 mL	18.9165 mL	37.8329 mL	94.5823 mL
DMSO	5 mM	0.7567 mL	3.7833 mL	7.5666 mL	18.9165 mL
	10 mM	0.3783 mL	1.8916 mL	3.7833 mL	9.4582 mL
	15 mM	0.2522 mL	1.2611 mL	2.5222 mL	6.3055 mL
	20 mM	0.1892 mL	0.9458 mL	1.8916 mL	4.7291 mL
	25 mM	0.1513 mL	0.7567 mL	1.5133 mL	3.7833 mL
	30 mM	0.1261 mL	0.6305 mL	1.2611 mL	3.1527 mL
	40 mM	0.0946 mL	0.4729 mL	0.9458 mL	2.3646 mL
	50 mM	0.0757 mL	0.3783 mL	0.7567 mL	1.8916 mL
	60 mM	0.0631 mL	0.3153 mL	0.6305 mL	1.5764 mL
	80 mM	0.0473 mL	0.2365 mL	0.4729 mL	1.1823 mL
	100 mM	0.0378 mL	0.1892 mL	0.3783 mL	0.9458 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Abscisic acid

4 Cited Publications

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Abscisic acid

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Publications Citing Use of MedChemExpress (MCE) Abscisic acid

Ver todos los productos específicos de isoformas ABA Receptor

Ver todos los productos específicos de isoformas Endogenous Metabolite

Actividad biológica

Chemical Information

Publications (4)

Solvente y solubilidad

Pureza y Documentación

Referencias

Help & FAQs

Complete Stock Solution Preparation Table

Abscisic acid Related Classifications

HY-100560 Related Classifications