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Referencia número: HY-10109A

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AS-605240 potassium

Name: AS-605240 potassium
Brand: MedChemExpress
SKU: HY-10109A
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4 Cited Publications

Revisión del cliente

Based on 4 publication(s) in Google Scholar

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC₅₀: 8 nM; K_i: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC₅₀ values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC₅₀ values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice.

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Fòrmula: C₁₂H₆KN₃O₂S
Peso molecular:295.36

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

AS-605240 potassium Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Publications (4)
Pureza y Documentación
Referencias
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

PI3Kγ

8 nM (IC₅₀)

Ver todos los productos específicos de isoformas PI3K :

Ver todos los productos específicos de isoformas Akt :

Chemical Information

Peso molecular 295.36
Fòrmula C₁₂H₆KN₃O₂S
SMILES

O=C([N-]C/1=O)SC1=C/C2=CC3=C(N=CC=N3)C=C2.[K+]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (4)

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Cell Syst

Torin2 Exploits Replication and Checkpoint Vulnerabilities to Cause Death of PI3K-Activated Triple-Negative Breast Cancer Cells. [Abstract]

2020 Jan 22;10(1):66-81.e11. PMID: 31812693
Drug Des Devel Ther

AS-605240 Blunts Osteoporosis by Inhibition of Bone Resorption. [Abstract]

2023 Apr 27:17:1275-1288. PMID: 37138583
Molecules

In Vitro and in Vivo Activity of mTOR Kinase and PI3K Inhibitors Against Leishmania donovani and Trypanosoma brucei. [Abstract]

2020 Apr 23;25(8):1980. PMID: 32340370
J Neurochem

Signaling pathways involved in NMDA-induced suppression of M-channels in corticotropin-releasing hormone neurons in central amygdala. [Abstract]

2022 Jun;161(6):478-491. PMID: 35583089

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Camps M, et al. Blockade of PI3Kgamma suppresses joint inflammation and damage in mouse models of rheumatoid arthritis. Nat Med. 2005 Sep;11(9):936-43. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

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Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AS-605240 potassium

4 Cited Publications

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
Chemical Information
Publications (4)
Pureza y Documentación
Referencias

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AS-605240 potassium

Publications Citing Use of MedChemExpress (MCE) AS-605240 potassium

Ver todos los productos específicos de isoformas PI3K

Ver todos los productos específicos de isoformas Akt

Actividad biológica

Chemical Information

Publications (4)

Pureza y Documentación

Referencias

Calculators

Help & FAQs

AS-605240 potassium Related Classifications

HY-10109A Related Classifications

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