BAY-805
Based on 4 publication(s) in Google Scholar
BAY-805, a chemical probe, is a selective inhibitor of ubiquitin-specific protease USP21. BAY-805 has high selectivity for deubiquitinating enzyme (DUB) targets, kinases, proteases and other common target enzymes.
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- Pureza: 99.67%
- No. CAS: 2925481-88-3
- Fòrmula: C24H28F3N5O2S
- Peso molecular:507.57
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Almacenamiento:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BAY-805
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Actividad biológica
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USP21 |
BAY-805 inhibits the activity of hUSP21 HTRF and hUSP21 Ub-Rhod with IC50 values of 6 nM and 2 nM, respectively[1].
BAY-805 (10 µM) induces the NF-κB activation with an EC50 value of 17 nM[1].
BAY-805 (10 µM and 50 µM) significantly inhibits the activity of USP21 and also shows weak influence on USP22 and USP10[1].
BAY-805 (0.0001-1000000 nM) selectively inhibits the activity of USP21[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2925481-88-3
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Appearance Solid
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Peso molecular 507.57
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Fòrmula C24H28F3N5O2S
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Color White to off-white
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SMILES
O=C([C@@H](CC(C)C)NC(C1(C(F)(F)F)CCCCC1)=O)NC2=NN=C(CC3=CC=C(C#N)C=C3)S2
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (4)
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Journal Impact Factor
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Most Recent
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Cell Mol Immunol
USP21 drives immune evasion in colorectal cancer via deubiquitination and stabilization of β-catenin. [Abstract]2026 Jun;23(6):701-718. PMID: 42091690 -
Cell Death Discov
2024 Dec 18;10(1):492. PMID: 39695128 -
Int J Biol Macromol
Ubiquitin-specific protease 21 aggravates enterovirus 71 (EV71) infection by restricting Lys48-linked ubiquitination of EV71-2A protease. [Abstract]2025 May 13:144202. PMID: 40373892 -
Solvente y solubilidad
DMSO : ≥ 200 mg/mL (394.03 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.9702 mL | 9.8509 mL | 19.7017 mL | 49.2543 mL |
| 5 mM | 0.3940 mL | 1.9702 mL | 3.9403 mL | 9.8509 mL | |
| 10 mM | 0.1970 mL | 0.9851 mL | 1.9702 mL | 4.9254 mL | |
| 15 mM | 0.1313 mL | 0.6567 mL | 1.3134 mL | 3.2836 mL | |
| 20 mM | 0.0985 mL | 0.4925 mL | 0.9851 mL | 2.4627 mL | |
| 25 mM | 0.0788 mL | 0.3940 mL | 0.7881 mL | 1.9702 mL | |
| 30 mM | 0.0657 mL | 0.3284 mL | 0.6567 mL | 1.6418 mL | |
| 40 mM | 0.0493 mL | 0.2463 mL | 0.4925 mL | 1.2314 mL | |
| 50 mM | 0.0394 mL | 0.1970 mL | 0.3940 mL | 0.9851 mL | |
| 60 mM | 0.0328 mL | 0.1642 mL | 0.3284 mL | 0.8209 mL | |
| 80 mM | 0.0246 mL | 0.1231 mL | 0.2463 mL | 0.6157 mL | |
| 100 mM | 0.0197 mL | 0.0985 mL | 0.1970 mL | 0.4925 mL |
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