JPS004
JPS004 is a HDAC1-3 PROTAC degrader. JPS004 can induce degradation of HDAC1-3 and induce histone acetylation. JPS004 can induce cancer cells apoptosis. JPS004 can be used for the research of cancer.
(Pink: HDAC1-3 ligand (HY-50934); Blue: VHL ligand (HY-125845); Black: linker).
Para uso exclusivo en investigación. No vendemos a pacientes.
- No. CAS: 2559747-12-3
- Fòrmula: C47H61N7O6S
- Peso molecular:852.10
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Ver todos los productos específicos de isoformas PROTACs
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Actividad biológica
|
VHL |
HDAC1 |
HDAC2 |
HDAC3 |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | EC50 |
4.3 μM
Compound: 1; JPS004
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Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
Cytotoxicity against human HCT-116 cells assessed as reduction in cell viability measured after 48 hrs by cell-titer glo assay
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[PMID: 35293758] |
JPS004 (10 μM, 24 h) efficiently degrades histone deacetylase 1, 2, and 3 and increases the acetylation levels of histone H3 at lysine 56 (H3K56ac) and histone H2B at lysine 5 (H2BK5ac) in HCT116 human colorectal cancer cells[1].
JPS004 (10 μM, 24 h) induces apoptosis but has no effect on the level of the anti-apoptotic protein cIAP2 in HCT116 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 2559747-12-3
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Peso molecular 852.10
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Fòrmula C47H61N7O6S
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SMILES
NC(C=CC=C1)=C1NC(C(C=C2)=CC=C2NC(CCCCCCCCCCC(N[C@@H](C(C)(C)C)C(N3[C@@H](C[C@H](C3)O)C(NCC4=CC=C(C5=C(N=CS5)C)C=C4)=O)=O)=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
JPS004 Related Classifications
HY-176904 Related Classifications
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