TL8-506
Based on 1 Customer Validation
TL8-506 is a specific TLR8 agonist with an EC50 of 30?nM. TL8-506 has immunomodulatory effects and can be used in the study of tuberculosis and cancer immunotherapy.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 95.0%
- No. CAS: 1268163-15-0
- Fòrmula: C20H17N3O2
- Peso molecular:331.37
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Almacenamiento:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
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Actividad biológica
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TLR8 30 nM (EC50) |
TL8-506 (1 μM; 18 h) can activate dendritic cells in blood and tumors, induce the secretion of pro-inflammatory cytokines and chemokines, and promote the activation and recruitment of T cells (TL8-506 synergized with IFN-γ or Poly(I:C))[1].
TL8-506 can specifically activate TLR8 in vitro in TLR8 transgenic mouse bone marrow cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mtb H37Rv treated female TLR8 transgenic mice aged 6 weeks old[2]
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Dosage:Twice, four weeks apart
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Administration:Intramuscular injection (i.m.); TL8-506 was in form of ESAT6-Alum-TL8-506.
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Result:Provided better protection against Mtb challenge compared to ESAT6-Alum. The CFU in the lungs of mice treated with ESAT6-Alum-TL8-506 was significantly lower than that in the ESAT6-Alum group.
Significantly lowered bacterial load in the lungs and livers of mice.
Significantly ameliorated the tuberculous pneumonia and alveolitis and reduced the numbers and the area of granulomas.
Significantly increased the proportion of central memory CD8+ T cells.
Chemical Information
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No. CAS 1268163-15-0
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Appearance Solid
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Peso molecular 331.37
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Fòrmula C20H17N3O2
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Color Light yellow to light brown
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SMILES
O=C(C1=CC2=CC=C(C3=CC=CC(C#N)=C3)C=C2N=C(N)C1)OCC
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
DMSO : 12.5 mg/mL (37.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
[1]. Jun Tang, et al. Toll-Like Receptor 8 Agonist Strengthens the Protective Efficacy of ESAT-6 Immunization to Mycobacterium tuberculosis Infection. Front Immunol. 2018 Jan 24;8:1972. [Content Brief]
[2]. He M, S, et al. Combinations of Toll-like receptor 8 agonist TL8-506 activate human tumor-derived dendritic cells. J Immunother Cancer. 2022 Jun;10(6):e004268. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.0178 mL | 15.0889 mL | 30.1777 mL | 75.4444 mL |
| 5 mM | 0.6036 mL | 3.0178 mL | 6.0355 mL | 15.0889 mL | |
| 10 mM | 0.3018 mL | 1.5089 mL | 3.0178 mL | 7.5444 mL | |
| 15 mM | 0.2012 mL | 1.0059 mL | 2.0118 mL | 5.0296 mL | |
| 20 mM | 0.1509 mL | 0.7544 mL | 1.5089 mL | 3.7722 mL | |
| 25 mM | 0.1207 mL | 0.6036 mL | 1.2071 mL | 3.0178 mL | |
| 30 mM | 0.1006 mL | 0.5030 mL | 1.0059 mL | 2.5148 mL |
TL8-506 Related Classifications
HY-20457 Related Classifications
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