2. Gene
  3. SLC27A5 - solute carrier family 27 member 5 Gene

SLC27A5 - solute carrier family 27 member 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2

Gene ID: 10998 | Gene type: protein coding

About SLC27A5

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,498,333-58,511,992 (from NCBI)

This gene has 8 transcripts (splice variants), 226 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 126.6) and testis (RPKM 2.0).

Summary

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

SLC27A5 Products(2)

mRNA Protein Name
NM_001321196.2 NP_001308125.1 long-chain fatty acid transport protein 5 isoform 2 precursor
NM_012254.3 NP_036386.1 long-chain fatty acid transport protein 5 isoform 1 precursor

SLC27A5 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (120 - 557)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (566 - 642)

  • 0
  • 200
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  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 5

bile acyl-CoA synthetase

BA-CoA ligase

Related Diseases

Diseases Alias
Bile Acid Coa Ligase Deficiency And Defective Amidation
Cholestasis, Benign Recurrent Intrahepatic, 1

Benign Recurrent Intrahepatic Cholestasis

BRIC1

Summerskill Syndrome

Bric

Summerskill-Walshe-Tygstrup Syndrome

Cholestasis, Benign Recurrent Intrahepatic

Benign Recurrent Intrahepatic Cholestasis 1

Benign Recurrent Intrahepatic Cholestasis Type 1

Bric Type 1

Low Gamma-Gt Familial Intrahepatic Cholestasis

Recurrent Familial Intrahepatic Cholestasis

Cholestasis, Benign Recurrent Intrahepatic 1

Mild Atp8b1 Deficiency

Recurrent Familial Intrahepatic Cholestasis 1

Abcb11-Related Intrahepatic Cholestasis

Atp8b1-Related Intrahepatic Cholestasis

Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

Progressive Intrahepatic Cholestasis

Cholestasis, Progressive Familial Intrahepatic 3

Bric - [Benign Recurrent Intrahepatic Cholestasis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13148 SLC27A5 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC27A5 RGD RGD:708535
Felis catus SLC27A5 VGNC VGNC:65292
Mus musculus SLC27A5 MGD MGI:1347100
Macaca mulatta SLC27A5 VGNC VGNC:77442
Bos taurus SLC27A5 VGNC VGNC:34789