SLC27A5 - solute carrier family 27 member 5 Gene

Also Known as BAL; ACSB; BACS; FATP5; ACSVL6; FACVL3; FATP-5; VLACSR; VLCSH2; VLCS-H2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10998

About SLC27A5

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:58,498,333-58,511,992 (from NCBI)

This gene has 8 transcripts (splice variants), 226 orthologues, 12 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 126.6) and testis (RPKM 2.0).

Summary

The protein encoded by this gene is an isozyme of very long-chain acyl-CoA synthetase (VLCS). It is capable of activating very long-chain fatty-acids containing 24- and 26-carbons. It is expressed in liver and associated with endoplasmic reticulum but not with peroxisomes. Its primary role is in fatty acid elongation or complex lipid synthesis rather than in degradation. This gene has a mouse ortholog. [provided by RefSeq, Jul 2008]

SLC27A5 Products (2)

mRNA Protein Name
NM_001321196.2 NP_001308125.1 long-chain fatty acid transport protein 5 isoform 2 precursor
NM_012254.3 NP_036386.1 long-chain fatty acid transport protein 5 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cholate-CoA ligase activity IDA
IDA: Inferred from direct assay
10749848 GOA
enables long-chain fatty acid transmembrane transporter activity IDA
IDA: Inferred from direct assay
20530735 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables very long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
10479480 GOA
Biological Process GO Annotation Evidence References Source
involved in bile acid biosynthetic process IDA
IDA: Inferred from direct assay
11980911 GOA
involved in very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
10479480 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
10479480 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
11980911 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC27A5 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (120 - 557)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (566 - 642)

  • 0
  • 200
  • 400
  • 600
  • 690 a.a.
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 5

bile acyl-CoA synthetase

  • BA-CoA ligase

SLC27A5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC27A5 Q9Y2P5 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
SLC27A5 Q9Y2P5 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

SLC27A5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84889 SLC27A5 Antibody (YA4586) IHC-P, ELISA Human, Mouse
HY-P84889A SLC27A5 Antibody (YA4586)(PBS only) IHC-P, ELISA Human, Mouse

Related Diseases

Diseases Alias
Bile Acid Coa Ligase Deficiency And Defective Amidation
Cholestasis, Benign Recurrent Intrahepatic, 1

  • Benign Recurrent Intrahepatic Cholestasis

  • BRIC1

  • Summerskill Syndrome

  • Bric

  • Summerskill-Walshe-Tygstrup Syndrome

  • Cholestasis, Benign Recurrent Intrahepatic

  • Benign Recurrent Intrahepatic Cholestasis 1

  • Benign Recurrent Intrahepatic Cholestasis Type 1

  • Bric Type 1

  • Low Gamma-Gt Familial Intrahepatic Cholestasis

  • Recurrent Familial Intrahepatic Cholestasis

  • Cholestasis, Benign Recurrent Intrahepatic 1

  • Mild Atp8b1 Deficiency

  • Recurrent Familial Intrahepatic Cholestasis 1

  • Abcb11-Related Intrahepatic Cholestasis

  • Atp8b1-Related Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

  • Progressive Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic 3

  • Bric - [Benign Recurrent Intrahepatic Cholestasis]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13148 SLC27A5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus SLC27A5 RGD RGD:708535
Felis catus SLC27A5 VGNC VGNC:65292
Mus musculus SLC27A5 MGD MGI:1347100
Macaca mulatta SLC27A5 VGNC VGNC:77442
Bos taurus SLC27A5 VGNC VGNC:34789
Others SLC27A5 NCBI