SLC27A4 - solute carrier family 27 member 4 Gene

Also Known as IPS; FATP4; ACSVL4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10999

About SLC27A4

Cytogenetic location: 9q34.11 Genomic coordinates (GRCh38): 9:128,340,527-128,361,470 (from NCBI)

This gene has 2 transcripts (splice variants), 248 orthologues, 12 paralogues and is associated with 3 phenotypes. Broad expression in duodenum (RPKM 32.2), small intestine (RPKM 21.2) and 24 other tissues.

Summary

This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the Insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]

SLC27A4 Products (1)

mRNA Protein Name
NM_005094.4 NP_005085.2 long-chain fatty acid transport protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables long-chain fatty acid transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21395585 GOA
enables long-chain fatty acid-CoA ligase activity IDA
IDA: Inferred from direct assay
22022213 GOA
enables oleoyl-CoA ligase activity IDA
IDA: Inferred from direct assay
25603556 GOA
enables palmitoyl-CoA ligase activity IDA
IDA: Inferred from direct assay
25603556 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of GTPase activity IDA
IDA: Inferred from direct assay
25603556 GOA
acts upstream of or within fatty acid metabolic process IDA
IDA: Inferred from direct assay
25603556 GOA
involved in fatty acid transport IMP
IMP: Inferred from mutant phenotype
32521232 GOA
involved in lipid transport across blood-brain barrier IMP
IMP: Inferred from mutant phenotype
21395585 GOA
involved in long-chain fatty acid import into cell IDA
IDA: Inferred from direct assay
22022213 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
22022213 GOA
involved in long-chain fatty acid transport IMP
IMP: Inferred from mutant phenotype
21395585 GOA
involved in negative regulation of insulin receptor signaling pathway IDA
IDA: Inferred from direct assay
25603556 GOA
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
25603556 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
32521232 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
22022213 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC27A4 Protein Structure

AMP-binding

AMP-binding: AMP-binding enzyme (80 - 511)

AMP-binding_C

AMP-binding_C: AMP-binding enzyme C-terminal domain (520 - 595)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 600
  • 643 a.a.
Protein Preferred Names Protein Names

long-chain fatty acid transport protein 4

  • arachidonate--CoA ligase

Recombinant SLC27A4 Proteins

Cat. No. Product Name Accession Purity
HY-P77206 SLC27A4/FATP4 Protein, Human (HEK293, His) Q6P1M0-1 (Q483-L643) ≥ 90%, as determined by reducing SDS-PAGE.

SLC27A4 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82243 SLC27A4 Antibody (YA1988) WB, ICC/IF, IP Human
HY-P82243A SLC27A4 Antibody (YA1988)(PBS only) WB, ICC/IF, IP Human

Related Diseases

Diseases Alias
Ichthyosis Prematurity Syndrome

  • IPS

  • Ichthyosis Congenita Iv

  • Ichthyosis-Prematurity Syndrome

  • Congenital Ichthyosis Type 4
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Autosomal Recessive Congenital Ichthyosis

  • Lamellar Ichthyosis

  • Congenital Ichthyosiform Erythroderma

  • Li

  • Congenital Nonbullous Ichthyosiform Erythroderma

  • Arci

  • Congenital Lamellar Ichthyosis

  • Nonbullous Congenital Ichthyosiform Erythroderma

  • Cie

  • Congenital Non-Bullous Ichthyosiform Erythroderma

  • Erythrodermic Ichthyosis

  • Nbcie

  • Ncie

  • Non-Bullous Congenital Ichthyosiform Erythroderma

  • Collodion Baby

  • Ichthyosis, Lamellar

  • Non Bullous Congenital Ichthyosiform Erythroderma

  • Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form

  • Ichthyosiform Erythroderma, Congenital, Nonbullous, 1

  • Collodion Baby Syndrome

  • Ichthyoses, Lamellar

  • Nbie

  • Nonbullous Ichthyosiform Erythroderma

  • Classic Lamellar Ichthyosis

  • Ichthyosiform Erythroderma Nonbullous Congenital

  • Ichthyosiform Erythroderma Congenital

  • Ichthyosis, Congenital, Autosomal Recessive

  • Ichthyosiform Erythroderma, Congenital

  • Collodion Fetus

  • Non-Bullous Ichthyosiform Erythroderma
Lethal Restrictive Dermopathy

  • Hyperkeratosis-Contracture Syndrome

  • Tight Skin Contracture Syndrome

  • Tight Skin Contracture Syndrome, Lethal

  • Dermopathy, Restrictive, Lethal
Optic Disc Anomalies With Retinal And/Or Macular Dystrophy

  • Colobomatous Optic Disc-Macular Atrophy-Chorioretinopathy Syndrome

  • ODRMD

  • Optic Disk Anomalies With Retinal And/Or Macular Dystrophy
Ichthyosis, Congenital, Autosomal Recessive 1

  • Collodion Fetus

  • Autosomal Recessive Congenital Ichthyosis 1

  • ARCI1

  • Ichthyosis Congenita

  • Lamellar Exfoliation Of Newborn

  • Desquamation Of Newborn

  • Ichthyosis Congenita Ii

  • Shcb

  • Icr2

  • Bathing Suit Ichthyosis

  • Li1

  • Self-Healing Collodion Baby

  • Ichthyosis, Congenital, Autosomal Recessive 1, With Bathing Suit Distribution

  • Collodion Baby, Self-Healing

  • Ichthyosis, Lamellar, 1, Formerly

  • Li1, Formerly

  • Ichthyosis Lamellar 1

  • Lamellar Ichthyosis, Type 1

  • Bsi

  • Autosomal Recessive Congenital Ichthyosis 1 With Bathing Suit Distribution

  • Autosomal Recessive Congenital Ichthyosis Tgm1-Related

  • Lamellar Ichthyosis 1

  • Non-Erythrodermic Ichthyosis

  • Ichthyosis, Congenital, Autosomal Recessive, Type 1

  • Congenital Ichthyosis
Persistent Fetal Circulation Syndrome

  • Persistent Fetal Circulation

  • Fetal Circulation

  • Persistent Pulmonary Hypertension Of The Newborn

  • Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

  • Persistent Foetal Circulation

  • Persistent Foetal Circulation Syndrome

  • Pfc - [Persistent Fetal Circulation] Syndrome

  • Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

  • Newborn Pulmonary Hypertension

  • Primary Pulmonary Hypertension Of Newborn
Platelet Glycoprotein Iv Deficiency

  • Platelet-Type Bleeding Disorder 10

  • Bdplt10

  • Cd36 Deficiency

  • Bleeding Disorder, Platelet-Type, 10

  • PG4D

  • Bleeding Disorder Platelet-Type 10

  • Deficiency, Platelet Glycoprotein Iv
Ichthyosis, Congenital, Autosomal Recessive 4b

  • Harlequin Ichthyosis

  • Autosomal Recessive Congenital Ichthyosis 4b

  • Hi

  • Harlequin Fetus

  • ARCI4B

  • Ichthyosis Congenita, Harlequin Fetus Type

  • Harlequin Type Ichthyosis

  • 'Harlequin Fetus'

  • Harlequin Type Ichthyosis Congenita

  • Harlequin Type Ichthyosis Fetalis

  • Harlequin Baby Syndrome

  • Ichthyosis Congenita, Harlequin Type

  • Ichthyosis Fetalis, Harlequin Type

  • Ichthyosis Congenita Harlequin Fetus Type

  • Ichthyosis, Harlequin

  • Ichthyosis, Congenital, Autosomal Recessive, Type 4b
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13147 SLC27A4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18726 Slc27a4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25213 Slc27a4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SLC27A4 MGD MGI:1347347
Felis catus SLC27A4 VGNC VGNC:65291
Canis familiaris SLC27A4 VGNC VGNC:46332
Rattus norvegicus SLC27A4 RGD RGD:1307383
Bos taurus SLC27A4 VGNC VGNC:34788
Macaca mulatta SLC27A4 VGNC VGNC:77441
Others SLC27A4 NCBI