CYB561D2 - cytochrome b561 family member D2 Gene

Also Known as 101F6; TSP10; TSCytb; XXcos-LUCA11.4

Species: Homo sapiens (human)

Gene Type: protein coding
Gene ID: 11068

Summary

Enables heme binding activity and transmembrane monodehydroascorbate reductase activity. Involved in ascorbate homeostasis. Predicted to be located in vesicle. Predicted to be active in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

CYB561D2 Products (1)

mRNA Protein Name
NM_001291284.2 NP_001278213.1 transmembrane reductase CYB561D2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
19734123 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables transmembrane monodehydroascorbate reductase activity IDA
IDA: Inferred from direct assay
23235316 GOA
Biological Process GO Annotation Evidence References Source
involved in ascorbate homeostasis IDA
IDA: Inferred from direct assay
23235316 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane reductase CYB561D2

  • cytochrome b561 domain-containing protein 2

  • putative tumor suppressor protein 101F6

  • transmembrane ascorbate ferrireductase

  • tumor suppressor cytochrome b561

CYB561D2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYB561D2 O14569 PGRMC2 Homo sapiens O15173
Validated Y2H
32296183
Intra
CYB561D2 O14569 PGRMC2 Homo sapiens O15173
Y2H Array
32296183
Intra
CYB561D2 O14569 PGRMC2 Homo sapiens O15173
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 RMDN3 Homo sapiens Q96TC7
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 RMDN3 Homo sapiens Q96TC7
Validated Y2H
32296183
Intra
CYB561D2 O14569 RMDN3 Homo sapiens Q96TC7
Y2H Array
32296183
Intra
CYB561D2 O14569 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CYB561D2 O14569 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CYB561D2 O14569 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
CYB561D2 O14569 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 GPX8 Homo sapiens Q8TED1
Y2H Array
32296183
Intra
CYB561D2 O14569 PDE4A Homo sapiens P27815-4
Validated Y2H
32296183
Intra
CYB561D2 O14569 PDE4A Homo sapiens P27815-4
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 PDE4A Homo sapiens P27815-4
Y2H Array
32296183
Intra
CYB561D2 O14569 PTPN5 Homo sapiens P54829
Validated Y2H
32296183
Intra
CYB561D2 O14569 PTPN5 Homo sapiens P54829
Y2H Array
32296183
Intra
CYB561D2 O14569 PTPN5 Homo sapiens P54829
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 TMEM154 Homo sapiens Q6P9G4
Validated Y2H
32296183
Intra
CYB561D2 O14569 TMEM154 Homo sapiens Q6P9G4
Y2H Array
32296183
Intra
CYB561D2 O14569 TMEM154 Homo sapiens Q6P9G4
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 SLC18A1 Homo sapiens P54219-3
Validated Y2H
32296183
Intra
CYB561D2 O14569 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
CYB561D2 O14569 CLEC14A Homo sapiens Q86T13
Validated Y2H
32296183
Intra
CYB561D2 O14569 CLEC14A Homo sapiens Q86T13
Y2H Array
32296183
Intra
CYB561D2 O14569 CLEC14A Homo sapiens Q86T13
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CYB561D2 O14569 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CYB561D2 O14569 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
CYB561D2 O14569 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
CYB561D2 O14569 CREB3L1 Homo sapiens Q96BA8
Y2H Array
32296183
Intra
CYB561D2 O14569 CREB3L1 Homo sapiens Q96BA8
Validated Y2H
32296183
Intra
CYB561D2 O14569 CREB3L1 Homo sapiens Q96BA8
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 COQ9 Homo sapiens O75208
Validated Y2H
32296183
Intra
CYB561D2 O14569 COQ9 Homo sapiens O75208
Y2H Array
32296183
Intra
CYB561D2 O14569 COQ9 Homo sapiens O75208
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
CYB561D2 O14569 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
CYB561D2 O14569 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
CYB561D2 O14569 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
CYB561D2 O14569 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CYB561D2 O14569 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
CYB561D2 O14569 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
CYB561D2 O14569 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Intra
CYB561D2 O14569 SLC30A2 Homo sapiens Q9BRI3
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction