PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

Homo sapiens

Also known as MOSP; PLIP; DUSP23; PNAS-129

Gene ID: 114971 | Gene type: protein coding

About PTPMT1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,565,599-47,573,461 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 173 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 16.1), brain (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PTPMT1 Products(2)

mRNA	Protein	Name
NM_001143984.2	NP_001137456.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NM_175732.3	NP_783859.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 1

PTPMT1 Protein Structure

DSPc

0
100
201 a.a.

Protein Preferred Names

Protein Names

phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

NB4 apoptosis/differentiation related protein

Recombinant PTPMT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76556	PTPMT1 Protein, Human (His)	Q8WUK0 (K28-T201)	≥95%

Related Diseases

Diseases

Alias

Mitochondrial Complex Ii Deficiency

Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency	Isolated Succinate-Coenzyme Q Reductase Deficiency
Isolated Succinate-Coq Reductase Deficiency	Isolated Succinate-Ubiquinone Reductase Deficiency
Mitochondrial Respiratory Chain Complex Ii Deficiency	Complex 2 Mitochondrial Respiratory Chain Deficiency
Succinate Coq Reductase Deficiency	Succinate Dehydrogenase Deficiency
Isolated Succinate Dehydrogenase Deficiency	Succinate-Coenzyme Q Reductase Deficiency

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Myopathy, Centronuclear, X-Linked

X-Linked Myotubular Myopathy	Xlmtm
X-Linked Centronuclear Myopathy	Xlcnm
CNMX	Mtm1
Myotubular Myopathy, X-Linked	Mtmx
Myotubular Myopathy 1	Centronuclear Myopathy X-Linked
Myotubular Myopathy	Mtm
Cnm	Xmtm
Myotubular Myopathy Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-108547	Alexidine dihydrochloride	99.59%	Unkown
HY-RS11414	PTPMT1 Human Pre-designed siRNA Set A	/	Unkown
HY-B1474	Alexidine	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPMT1	VGNC	VGNC:45166
Rattus norvegicus	PTPMT1	RGD	RGD:1589783
Macaca mulatta	PTPMT1	VGNC	VGNC:110527
Bos taurus	PTPMT1	VGNC	VGNC:33528
Mus musculus	PTPMT1	MGD	MGI:1913711
Others	PTPMT1	NCBI

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