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PTPMT1 - protein tyrosine phosphatase mitochondrial 1 Gene

Also Known as MOSP; PLIP; DUSP23; PNAS-129

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 114971

About PTPMT1

Cytogenetic location: 11p11.2 Genomic coordinates (GRCh38): 11:47,565,599-47,573,461 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 173 orthologues and 30 paralogues. Ubiquitous expression in testis (RPKM 16.1), brain (RPKM 11.9) and 25 other tissues.

Summary

Predicted to enable phosphatidylglycerophosphatase activity and phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity. Involved in regulation of intrinsic apoptotic signaling pathway. Located in mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

PTPMT1 Products (2)

mRNA	Protein	Name
NM_001143984.2	NP_001137456.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 2
NM_175732.3	NP_783859.1	phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21516116	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in regulation of intrinsic apoptotic signaling pathway	IGI IGI: Inferred from genetic interaction	24709986	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in mitochondrion	IDA IDA: Inferred from direct assay	38322995	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTPMT1 Protein Structure

DSPc

0
100
201 a.a.

Protein Preferred Names	Protein Names
phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1	NB4 apoptosis/differentiation related protein

PTPMT1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PTPMT1	Q8WUK0	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	KRT40	Homo sapiens	Q6A162	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	KRTAP10-9	Homo sapiens	P60411	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	KRTAP10-7	Homo sapiens	P60409	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	ADAMTSL4	Homo sapiens	Q6UY14-3	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	RGS20	Homo sapiens	O76081-6	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	KRTAP2-3	Homo sapiens	P0C7H8	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	KRTAP2-3	Homo sapiens	P0C7H8	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP9-2	Homo sapiens	Q9BYQ4	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	LCE2C	Homo sapiens	Q5TA81	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	LCE2C	Homo sapiens	Q5TA81	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	TRIM27	Homo sapiens	P14373	Y2H Array	25416956
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	MDFI	Homo sapiens	Q99750	Y2H	21516116
Intra	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRTAP4-12	Homo sapiens	Q9BQ66	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	GRN	Homo sapiens	P28799	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	GRN	Homo sapiens	P28799	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	PTPMT1	Q8WUK0	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Validated Y2H	32296183
Intra	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Prey Pooling	32296183
Intra	PTPMT1	Q8WUK0	KRTAP3-1	Homo sapiens	Q9BYR8	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PTPMT1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76556	PTPMT1 Protein, Human (His)	Q8WUK0-1 (K28-T201)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Mitochondrial Complex Ii Deficiency	Isolated Mitochondrial Respiratory Chain Complex Ii Deficiency Isolated Succinate-Coenzyme Q Reductase Deficiency Isolated Succinate-Coq Reductase Deficiency Isolated Succinate-Ubiquinone Reductase Deficiency Mitochondrial Respiratory Chain Complex Ii Deficiency Complex 2 Mitochondrial Respiratory Chain Deficiency Succinate Coq Reductase Deficiency Succinate Dehydrogenase Deficiency Isolated Succinate Dehydrogenase Deficiency Succinate-Coenzyme Q Reductase Deficiency
Barth Syndrome	3-Methylglutaconic Aciduria Type 2 BTHS Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria Mga Type Ii Mga2 Mgca2 Mga Type 2 3-Methylglutaconic Aciduria Type Ii 3-Methylglutaconic Aciduria, Type Ii Mga, Type Ii 3-Methylglutaconicaciduria Type 2 3-Methylglutaconicaciduria Type Ii Taz Defect 3 Methylglutaconic Aciduria, Type Ii Dnajc19 Defect Cardioskeletal Myopathy-Neutropenia Syndrome X-Linked Cardioskeletal Myopathy And Neutropenia 3-Alpha-Methylglutaconic Aciduria Type 2 Agm2 Cardioskeletal Myopathy-Neutropenia Invm Left Ventricular Non-Compaction Isolated X-Linked Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked Agammaglobulinemia 2, Autosomal Recessive
Myopathy, Centronuclear, X-Linked	X-Linked Myotubular Myopathy Xlmtm X-Linked Centronuclear Myopathy Xlcnm CNMX Mtm1 Myotubular Myopathy, X-Linked Mtmx Myotubular Myopathy 1 Centronuclear Myopathy X-Linked Myotubular Myopathy Mtm Cnm Xmtm Myotubular Myopathy Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108547	Alexidine dihydrochloride		99.68%	Unkown
HY-B1474	Alexidine	Inhibitor	/	Unkown
HY-RS11414	PTPMT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-B1474S1	Alexidine-d10	Inhibitor	/	Unkown
HY-RS18311	Ptpmt1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24789	Ptpmt1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PTPMT1	VGNC	VGNC:45166
Rattus norvegicus	PTPMT1	RGD	RGD:1589783
Macaca mulatta	PTPMT1	VGNC	VGNC:110527
Bos taurus	PTPMT1	VGNC	VGNC:33528
Mus musculus	PTPMT1	MGD	MGI:1913711
Others	PTPMT1	NCBI