FCRL3 - Fc receptor like 3 Gene

Also Known as FCRH3; IFGP3; IRTA3; SPAP2; CD307c

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 115352

About FCRL3

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,676,481-157,700,956 (from NCBI)

This gene has 12 transcripts (splice variants), 55 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 31.5), spleen (RPKM 20.4) and 2 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

FCRL3 Products (2)

mRNA Protein Name
NM_001320333.2 NP_001307262.1 Fc receptor-like protein 3 isoform 3 precursor
NM_052939.4 NP_443171.2 Fc receptor-like protein 3 isoform 1 precursor

FCRL3 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (28 - 90)

Ig_2

Ig_2: Immunoglobulin domain (108 - 185)

Ig_2

Ig_2: Immunoglobulin domain (192 - 271)

Ig_2

Ig_2: Immunoglobulin domain (292 - 376)

Ig_3

Ig_3: Immunoglobulin domain (383 - 451)

Ig_3

Ig_3: Immunoglobulin domain (475 - 548)

  • 0
  • 200
  • 400
  • 600
  • 734 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 3

  • Fc receptor homolog 3

FCRL3 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84737 CD307C Antibody (YA4434) WB, FC, ELISA Human
HY-P84737A CD307C Antibody (YA4434)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Arthritis

  • Inflammatory Joint Disease

  • Inflammatory Disorder Of Joint
Rheumatoid Arthritis

  • RA

  • Arthritis, Rheumatoid

  • Rheumatoid Arthritis, Susceptibility To

  • Arthritis Or Polyarthritis, Rheumatic

  • Atrophic Arthritis

  • Rheumatism Arthritis

  • Rheumatoid Polyarthritis
Graves' Disease

  • Graves Disease

  • Exophthalmic Goiter

  • Basedow'S Disease

  • Grave'S Disease

  • Basedow Disease

  • Toxic Diffuse Goiter

  • Graves' Hyperthyroidism

  • Parry Disease

  • Autoimmune Hyperthyroidism

  • Toxic Multinodular Goiter
Lupus Erythematosus

  • Lupus

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus, Systemic

  • Subacute Cutaneous Lupus

  • Le - [Lupus Erythematosus]
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Immunodeficiency 48

  • Combined Immunodeficiency Due To Zap70 Deficiency

  • IMD48

  • Selective T-Cell Defect

  • Stcd

  • Zeta-Associated-Protein 70 Deficiency

  • Severe Combined Immunodeficiency, Atypical

  • Immunodeficiency, Type 48

  • Zap70 Deficiency
Systemic Lupus Erythematosus

  • Lupus Nephritis

  • SLE

  • Disseminated Lupus Erythematosus

  • Systemic Lupus Erythematosus, Susceptibility To

  • Lupus Erythematosus, Systemic

  • Lupus Nephritis, Susceptibility To

  • Libman-Sacks Disease

  • Systemic Lupus Erythematosus Susceptibility To

  • Sle - Lupus Erythematosus, Systemic

  • Le Syndrome

  • Lupus

  • Lupus Erythematosus Systemic

  • Lupus Erythematosus, Systemic, Susceptibility To

  • Lupus Vulgaris

  • Lupus Erythematosus, Discoid

  • Lupus Erythematosus

  • Systemic Lupus Erythematosus Nos

  • Sle - [Systemic Lupus Erythematosus]
Multiple Sclerosis

  • MS

  • Multiple Sclerosis, Susceptibility To

  • Disseminated Sclerosis

  • Multiple Sclerosis, Disease Progression, Modifier Of

  • Insular Sclerosis

  • Multiple Sclerosis Modifier Of Disease Progression

  • Multiple Sclerosis, Susceptibility To 1

  • Multiple Sclerosis, Susceptibility To, 1

  • Multiple Sclerosis 1

  • Generalized Multiple Sclerosis

  • Multiple Sclerosis Variant

  • Multiple Sclerosis Susceptibility To

  • Cerebrospinal Sclerosis

  • Generalised Multiple Sclerosis

  • Ms - [Multiple Sclerosis]

  • Disseminated Cerebrospinal Sclerosis

  • Disseminated Multiple Sclerosis

  • Disseminated Nervous System Myelosclerosis

  • Multiple Cerebrospinal Sclerosis

  • Multiple Combined Sclerosis

  • Multiple Sclerosis Generalised

  • Disseminated Brain Sclerosis

  • Disseminated Spinal Sclerosis

  • Insular Brain Sclerosis

  • Miliary Brain Sclerosis

  • Multiple Combined Sclerosis Of Spinal Cord

  • Multiple Ascending Sclerosis

  • Multiple Brain Sclerosis

  • Multiple Sclerosis Of Brain Stem

  • Multiple Sclerosis Of The Brain Stem

  • Multiple Sclerosis Of Cord

  • Sclérose En Plaques

  • Plaque Sclerosis

  • Multiple Sclerosis Of The Spinal Cord
Autoimmune Pancreatitis

  • Lymphoplasmocytic Sclerosing Pancreatitis

  • Aip
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04844 FCRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25681 Fcrl5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus FCRL3 VGNC VGNC:50048
Felis catus FCRL3 VGNC VGNC:62215
Macaca mulatta FCRL3 VGNC VGNC:99949
Mus musculus FCRL3 MGD MGI:3053558
Others FCRL3 NCBI