CD307C Antibody (YA4434)
(Synonyms: FCRL3; FCRH3; IFGP3; IRTA3; SPAP2)CD307C Antibody (YA4434) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD307C.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, FC, ELISA
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Reactivity :
Human
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Formulation:
Supplied in PBS with 0.05% sodium azide
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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FC
FC: Flow Cytometry
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:400 | 1:10000 |
Product Details
CD307C Antibody (YA4434) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to CD307C.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 51 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 80.9 kDa
Purified recombinant fragment of human CD307C (AA: extra 18-153) expressed in E. Coli.
affinity purified.
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Supplied in PBS with 0.05% sodium azide
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
CD307C promotes TLR9-induced B-cell proliferation, activation and survival but inhibits antibody production and suppresses plasma cell differentiation. Enhances activation of NF-kappa-B and MAPK signaling pathways in TLR9 stimulated B-cells. Has inhibitory potentional on B-cell receptor (BCR)-mediated signaling, possibly through association with SH2 domain-containing phosphatases. Inhibits cell tyrosine phosphorylation, calcium mobilization and activation-induced cell death induced through BCR signaling. Regulatory T-cells expressing FCRL3 exhibit a memory phenotype, are relatively nonresponsive to antigenic stimulation in presence of IL2 and have reduced capacity to suppress the proliferation of effector T-cells. Acts as a human-specific epitope on the cell surface of oocytes (oolemma) and plays a role during sperm-egg adhesion and fusion. Interacts with the IZUMO1-IZUMO1R/JUNO sperm-egg complex and replaces IZUMO1R/JUNO as IZUMO1 receptor during fertilization, thereby permitting species-specific gamete fusion[1][2][3][4][5].
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Cell projection, microvillus membrane
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Expression
Tissue_specificity:Primarily expressed in secondary lymphoid tissues by mature subsets of B-cells. Low expression on transitional B cells which increases to higher surface expression on mature and memory B-cells with innate-like features (at protein level) (PubMed:23857366) . Expressed a low levels in naive and germinal center B-cells but also expressed in NK cells (at protein level) (PubMed:20190142) . Expressed in unfertilized oocytes (at protein level) (PubMed:36070373) . Expressed in a population of thymically derived naturally occurring regulatory T-cells that exhibits a memory phenotype, specialized in suppressing immune response to self-antigens (PubMed:20190142) . Detected in spleen, lymph node, peripheral blood lymphocytes, thymus, bone marrow, kidney, salivary gland, adrenal gland and uterus -
Isoforms & Post-Translational Modification
Q96P31 has 7 isomers: Q96P31-1: 80856 Da (predicted); Q96P31-2: 69929 Da (predicted); Q96P31-3: 81441 Da (predicted); Q96P31-4: 21441 Da (predicted); Q96P31-5: 22632 Da (predicted); Q96P31-6: 81853 Da (predicted); Q96P31-7: 77921 Da (predicted).
Phosphorylated on cytoplasmic tyrosines; required for interaction with protein tyrosine phosphatases and protein tyrosine kinases -
Subunit
Interacts (via phosphorylated ITIM motifs) with phosphatases INPP5D, PTPN6 and PTPN11. Interacts (via ITIM motifs) SYK and ZAP70. Interacts with IZUMO1R/JUNO (PubMed:36070373). Interacts (via extracellular domain) with IZUMO1; the interaction replaces IZUMO1R/JUNO as IZUMO1 receptor after adhesion between sperm and egg (PubMed:36070373)
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SwissProt ID
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Synonyms
FCRL3; FCRH3; IFGP3; IRTA3; SPAP2
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