SERPINA12 - serpin family A member 12 Gene

Also Known as OL-64

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 145264

About SERPINA12

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,487,279-94,517,844 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 63.5).

Summary

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA12 Products (3)

mRNA Protein Name
NM_001304461.2 NP_001291390.1 serpin A12 precursor
NM_001382267.1 NP_001369196.1 serpin A12 precursor
NM_173850.4 NP_776249.1 serpin A12 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables molecular function inhibitor activity IMP
IMP: Inferred from mutant phenotype
23370777 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SERPINA12 Protein Structure

Serpin

Serpin: Serpin (serine protease inhibitor) (51 - 411)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
Protein Preferred Names Protein Names

serpin A12

  • serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

SERPINA12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SERPINA12 Q8IW75 LAMB1 Homo sapiens P07942
Anti Tag CoIP
33961781
Intra
SERPINA12 Q8IW75 LAMB1 Homo sapiens P07942
Anti Tag CoIP
28514442
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SERPINA12 Proteins

Cat. No. Product Name Accession Purity
HY-P7419 Vaspin Protein, Human Q8IW75 (L21-K414) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P71299 Vaspin Protein, Human (GST) Q8IW75 (L21-K414) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P71300 Vaspin Protein, Human (HEK293, His) Q8IW75 (L21-K414) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Palmoplantar Keratoderma, Norrbotten Recessive Type

  • PPKNR

  • Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type

  • Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type

  • Ppk, Gamborg-Nielsen Type

  • Keratoderma, Palmoplantar, Norrbotten Recessive Type
Carotid Stenosis

  • Carotid Artery Stenosis

  • Stenosis, Carotid Artery
Type 2 Diabetes Mellitus

  • Insulin Resistance

  • NIDDM

  • Type 2 Diabetes

  • Diabetes Mellitus, Non-Insulin-Dependent

  • T2D

  • Noninsulin-Dependent Diabetes Mellitus

  • Diabetes Mellitus, Type Ii

  • Maturity-Onset Diabetes

  • Insulin Resistance, Severe, Digenic

  • Diabetes Mellitus, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent

  • Diabetes Mellitus, Noninsulin-Dependent, Association With

  • Diabetes Mellitus, Noninsulin-Dependent, Late Onset

  • Hypertension, Insulin Resistance-Related, Susceptibility To

  • Insulin Resistance, Susceptibility To

  • Non-Insulin-Dependent Diabetes Mellitus

  • Type Ii Diabetes Mellitus

  • Adult-Onset Diabetes Mellitus

  • Maturity-Onset Diabetes Mellitus

  • Diabetes Mellitus Type 2

  • Type Ii Diabetes

  • Type 2 Diabetes Mellitus, Susceptibility To

  • Diabetes, Type 2

  • Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

  • Diabetes Mellitus, Type 2, Susceptibility To

  • Diabetes Mellitus, Noninsulin-Dependent, 2

  • Diabetes Mellitus, Type Ii, Susceptibility To

  • Hypertension, Insulin Resistance-Related

  • Adult-Onset Diabetes

  • Aodm

  • Diabetes Mellitus, Adult-Onset

  • Diabetes Mellitus Type Ii

  • Diabetes Mellitus Type 2, Susceptibility To

  • Diabetes, Type Ii, Susceptibility To

  • Diabetes Type 2

  • Diabetes Mellitus

  • Adult Onset Diabetes

  • Maturity Onset Diabetes

  • Nonketotic Diabetes

  • Non-Insulin Dependent Diabetes Mellitus

  • T2dm - [Type 2 Diabetes Mellitus]

  • Niddm - [Non Insulin Dependent Diabetes Mellitus]

  • Dm2

  • Dm Type Ii

  • Diabetic Type 2

  • Insulin Requiring Type 2 Diabetes

  • Noninsulin Dependent Diabetes

  • Non-Insulin-Dependent Diabetes Mellitus Without Complications

  • Diabetes Due To Insulin Secretory Defect

  • Diabetes Mellitus Due To Insulin Secretory Defect

  • Non-Insulin-Dependent Diabetes Of The Young

  • Senile Diabetes

  • Nonketotic Hyperglycaemia

  • Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

  • OBESITY

  • Obesity, Susceptibility To

  • Leanness, Inherited

  • Obesity, Susceptibility To, Bmiq11

  • Obesity, Mild, Early-Onset

  • Obesity, Association With

  • Obesity, Early-Onset, Susceptibility To

  • Obesity, Severe

  • Obesity, Severe, And Type Ii Diabetes

  • Obesity, Late-Onset

  • Obesity , Susceptibility To

  • BMIQ11

  • Obesity Bmiq11

  • Obesity, Early-Onset

  • Simple Obesity Nos

  • Excess Fat

  • Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

  • Adiposis
Amelogenesis Imperfecta

  • Ai

  • Congenital Enamel Hypoplasia

  • Al - [Amelogenesis Imperfecta]
Diabetes Mellitus

  • Diabetes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12698 SERPINA12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20676 Serpina12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27187 Serpina12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SERPINA12 VGNC VGNC:77266
Felis catus SERPINA12 VGNC VGNC:65022
Mus musculus SERPINA12 MGD MGI:1915304
Rattus norvegicus SERPINA12 RGD RGD:708485
Canis familiaris SERPINA12 VGNC VGNC:51682
Others SERPINA12 NCBI