LAMB1 - laminin subunit beta 1 Gene

Also Known as CLM; LIS5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3912

About LAMB1

Cytogenetic location: 7q31.1 Genomic coordinates (GRCh38): 7:107,923,799-108,003,161 (from NCBI)

This gene has 37 transcripts (splice variants), 296 orthologues, 27 paralogues and is associated with 3 phenotypes. Broad expression in placenta (RPKM 75.7), fat (RPKM 65.2) and 23 other tissues.

Summary

Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with Other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis. [provided by RefSeq, Aug 2011]

LAMB1 Products (1)

mRNA	Protein	Name
NM_002291.3	NP_002282.2	laminin subunit beta-1 precursor

LAMB1 Protein Structure

Laminin_N

Laminin_EGF

0
300
600
900
1200
1500
1786 a.a.

Protein Preferred Names	Protein Names
laminin subunit beta-1	laminin B1 chain

LAMB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
Intra	LAMB1	P07942	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Prey Pooling	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Validated Y2H	32296183
Intra	LAMB1	P07942	UBQLN1	Homo sapiens	Q9UMX0	Y2H Array	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Validated Y2H	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Array	32296183
Intra	LAMB1	P07942	CD79A	Homo sapiens	P11912	Y2H Prey Pooling	32296183
Cross	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Crosslink	26438063
Cross	LAMB1	P07942	c5mbe7_cantt	Candida tropicalis	C5MBE7	Affinity Chrom	26438063

Cross: Cross-species interaction Intra: Intraspecies interaction

LAMB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80439	Laminin beta 1 Antibody (YA312)	WB, IHC-P, FC	Human, Mouse
HY-P85254	Laminin beta 1 Antibody (YA4946)	IHC-P, ELISA	Human
HY-P85254A	Laminin beta 1 Antibody (YA4946)(PBS only)	IHC-P, ELISA	Human
HY-P86418	Laminin beta 1 Antibody (YA6110)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Lissencephaly 5	LIS5 Cobblestone Lissencephaly Without Muscular Or Ocular Involvement Cobblestone Lissencephaly Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Eye Involvement Lissencephaly Type 2 Without Muscular Or Ocular Involvement Lissencephaly, Type 5
Cutis Laxa	Generalized Elastolysis Loose Skin Dermatolysis Dermatomegaly Cutis Laxa Syndrome
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Teratocarcinoma	Mixed Embryonal Carcinoma And Teratoma
Nephrotic Syndrome, Type 5, With Or Without Ocular Abnormalities	NPHS5 Nephrotic Syndrome Type 5 Nephrotic Syndrome Type 5, With Or Without Ocular Abnormalities Nephrotic Syndrome 5 With Or Without Ocular Abnormalities Nephrotic Syndrome, Type 5, With/Without Ocular Abnormalities
Junctional Epidermolysis Bullosa	Epidermolysis Bullosa, Junctional Jeb Epidermolysis Bullosa Atrophicans Congenital Junctional Epidermolysis Bullosa Epidermolysis Bullosa Junctional Junctional Eb - [Epidermolysis Bullosa] Jeb - [Junctional Epidermolysis Bullosa] Lucidolytic Epidermolysis Bullosa
Embryonal Carcinoma	Embryonal Neoplasm Embryonal Cancer Primary Extragonadal Embryonal Carcinoma Embryo Neoplasm Carcinoma Embryonal Cancer Embryonal Carcinoma, Embryonal Extragonadal Embryonal Carcinoma Cancer, Embryonal
Supravalvular Aortic Stenosis	SVAS Supravalvar Aortic Stenosis Supravalvar Aortic Stenosis, Eisenberg Type Aortic Supravalvular Stenosis Aortic Stenosis, Supravalvular Supra-Valvular Aortic Stenosis Stenosis, Aortic Supravalvular Stenosis, Supravalvular Aortic Supravalvular Stenosis, Aortic Aortic Stenosis Supravalvular
Hepatocellular Clear Cell Carcinoma	Clear Cell Carcinoma Of The Liver Cells Hepatocellular Carcinoma, Clear Cell Type Clear Cell Hepatocellular Carcinoma
Leiomyoma	Leiomyomatous Neoplasm Leiomyomatous Tumor Leiomyomas Fibroid Tumor Uterine Fibroids
Muscular Dystrophy	Muscular Dystrophies Congenital Md Congenital Muscular Dystrophy Cmd Mdc Dystrophy, Muscular Gower'S Muscular Dystrophy Progressive Musclular Dystrophy Pseudohypertrophic Atrophy Pseudohypertrophic Muscle Paralysis Pseudohypertrophic Muscular Atrophy Pseudohypertrophic Muscular Dystrophy Pseudohypertrophic Paralysis Pseudomuscular Hypertrophy
Diffuse Mesangial Sclerosis	Familial Mesangial Sclerosis Mesangial Sclerosis, Diffuse Dms Diffuse Isolated Mesangial Sclerosis Isolated Diffuse Mesangial Sclerosis Nephrotic Syndrome, Early Onset With Diffuse Mesangial Sclerosis
Leiomyomatosis
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Pierson Syndrome	Microcoria-Congenital Nephrotic Syndrome Microcoria-Congenital Nephrosis Syndrome PIERS Microcoria - Congenital Nephrosis Microcoria - Congenital Nephrotic Syndrome PIERSS
Myopathy	Muscular Diseases Myopathies
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-182561	Cgs 27830	Antagonist	/	Unkown
HY-N1045	13-Keto-8(14)-Podocarpen-18-oic acid		/	Unkown
HY-N1607	18-Nor-4,15-dihydroxyabieta-8,11,13-trien-7-one		/	Unkown
HY-RS07502	LAMB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N3766	Diosbulbin G		/	Unkown
HY-N4013	Imbricatoloic acid		/	Unkown
HY-RS21624	Lamb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28142	Lamb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	LAMB1	VGNC	VGNC:68006
Bos taurus	LAMB1	VGNC	VGNC:30772
Rattus norvegicus	LAMB1	RGD	RGD:1306311
Macaca mulatta	LAMB1	VGNC	VGNC:74228
Canis familiaris	LAMB1	VGNC	VGNC:42567
Mus musculus	LAMB1	MGD	MGI:96743
Others	LAMB1	NCBI