CYP2C8 - cytochrome P450 family 2 subfamily C member 8 Gene

Also Known as CPC8; CYPIIC8; CYP2C8DM; MP-12/MP-20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1558

About CYP2C8

Cytogenetic location: 10q23.33 Genomic coordinates (GRCh38): 10:95,036,772-95,069,497 (from NCBI)

This gene has 12 transcripts (splice variants), 30 orthologues, 15 paralogues and is associated with 59 phenotypes. Restricted expression toward liver (RPKM 350.3).

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of Cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

CYP2C8 Products (4)

mRNA	Protein	Name
NM_000770.3	NP_000761.3	cytochrome P450 2C8 isoform a precursor
NM_001198853.1	NP_001185782.1	cytochrome P450 2C8 isoform b
NM_001198854.1	NP_001185783.1	cytochrome P450 2C8 isoform c
NM_001198855.1	NP_001185784.1	cytochrome P450 2C8 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables arachidonate epoxygenase activity	IDA IDA: Inferred from direct assay	7574697	GOA
enables caffeine oxidase activity	IDA IDA: Inferred from direct assay	18619574	GOA
enables estrogen 16-alpha-hydroxylase activity	IDA IDA: Inferred from direct assay	14559847	GOA
enables monooxygenase activity	IDA IDA: Inferred from direct assay	15766564	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables retinoic acid 4-hydroxylase activity	IDA IDA: Inferred from direct assay	11093772	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in epoxygenase P450 pathway	IDA IDA: Inferred from direct assay	7574697	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	12865317	GOA
involved in icosanoid biosynthetic process	IDA IDA: Inferred from direct assay	15766564	GOA
involved in lipid hydroxylation	IDA IDA: Inferred from direct assay	14559847	GOA
involved in organic acid metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA
involved in oxidative demethylation	IDA IDA: Inferred from direct assay	18619574	GOA
involved in retinoic acid metabolic process	IDA IDA: Inferred from direct assay	11093772	GOA
involved in steroid metabolic process	IDA IDA: Inferred from direct assay	14559847	GOA
involved in xenobiotic catabolic process	IDA IDA: Inferred from direct assay	18619574	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	19651758	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP2C8 Protein Structure

p450

0
100
200
300
400
490 a.a.

Protein Preferred Names	Protein Names
cytochrome P450 2C8	P450 form 1

Related Diseases

Diseases	Alias
Drug Metabolism, Altered, Cyp2c8-Related	{Drug Metabolism, Altered, Cyp2c8-Related}
Osteonecrosis Of The Jaw
Sulfamethoxazole Allergy	Smx Allergy Smz Allergy Sulphamethoxazole Allergy
Gout	Gouty Arthritis Articular Gout Gouty Arthropathy Arthritis, Gouty Arthritis Gouty Idiopathic Gout Idiopathic Gout, Unspecified Site Gouty Bursitis Uratic Arthritis Gout Nos Gouty Gouty Diathesis
Osteonecrosis	Bone Necrosis Avascular Necrosis Of Bone Aseptic Necrosis Necrosis Of Bone Nos Aseptic Osteonecrosis Aseptic Necrosis Of Bone, Site Unspecified Aseptic Or Avascular Bone Necrosis Aseptic Necrosis Of Bone Necrotic Bone Necrotizing Bone Spontaneous Osteonecrosis Osteoradionecrosis
Hypertrophy Of Tongue Papillae	Tongue Papillary Hypertrophy Hypertrophy Of Foliate Papillae
Smallpox	Variola Ordinary Smallpox Alastrim Amaas
Coumarin Resistance	Warfarin Resistance Warfarin Sensitivity Coumadin Sensitivity Warfarin Response Poor Metabolism Of Coumarin Coumarin, Poor Metabolism Of CMRES
Gilbert Syndrome	Gilbert Disease Gilbert'S Disease Gilbert'S Syndrome Cholemia, Familial Familial Nonhemolytic Jaundice Meulengracht Syndrome Gilbert Syndrome, Susceptibility To Hyperbilirubinemia, Gilbert Type Hblrg Hyperbilirubinemia, Arias Type Hyperbilirubinemia I Constitutional Hyperbilirubinemia Gilbert-Meulengracht Syndrome Hereditary Nonhemolytic Jaundice Hyperbilirubinemia Arias Type Hyperbilirubinemia Type 1 Constitutional Liver Dysfunction Gilbert-Lereboullet Syndrome Hyperbilirubinemia 1 Unconjugated Benign Bilirubinemia GILBS Gilberts Syndrome Familial Nonhaemolytic Jaundice Constitutional Hyperbilirubinaemia Hereditary Nonhaemolytic Bilirubinaemia Familial Nonhaemolytic Bilirubinaemia Idiopathic Hyperbilirubinaemia Icterus Intermittens Juvenilis Chronic Intermittent Juvenile Jaundice Low-Grade Chronic Hyperbilirubinaemia Syndrome Benign Unconjugated Bilirubinaemia Syndrome Hereditary Nonhaemolytic Jaundice Idiopathic Unconjugated Hyperbilirubinaemia Gilbert--Lereboullet Syndrome Constitutional Hepatic Dysfunction Meulengracht Icterus Cholaemia Familiaris Simplex Familial Cholaemia Congenital Familial Cholaemia Physiologic Cholaemia Hyperbilirubinaemia Type 1 Gilbert Cholaemia
Bilirubin Metabolic Disorder	Hyperbilirubinemia Hereditary Hyperbilirubinemia Hyperbilirubinemia, Hereditary Hyperbilirubinaemia
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17356	Fenofibrate		99.97%	Yes

Pre-clinical Phase

Bioactive Molecules (50)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-129993	Gemfibrozil 1-O-β-glucuronide	Inhibitor	99.87%	Unkown
HY-N0319	Salvianolic acid C	Inhibitor	99.94%	Unkown
HY-W013268	(S)-(+)-N-3-Benzylnirvanol	Inhibitor	99.76%	Unkown
HY-114759	MS-PPOH	Inhibitor	99.05%	Unkown
HY-100641	4-Hydroxytolbutamide		99.69%	Unkown
HY-148352	BAY-4931	Antagonist	98.72%	Unkown
HY-163996	DD202-114		99.27%	Unkown
HY-100641S	4-Hydroxytolbutamide-d9		99.29%	Unkown
HY-125348	6α-Hydroxy paclitaxel		99.93%	Unkown
HY-135335	3'-Hydroxy Repaglinide		98.20%	Unkown
HY-135334	ACP-5862	Inhibitor	98.32%	Unkown
HY-70002AS	N-Desmethyl enzalutamide-d6	Antagonist	97.95%	Unkown
HY-135331	N-Desmethyl-Apalutamide		99.08%	Unkown
HY-116862	Dibenzylfluorescein		99.54%	Unkown
HY-147294	Nivasorexant		99.74%	Unkown
HY-17356R	Fenofibrate (Standard)		99.92%	Unkown
HY-W587878	Thujopsene		86.31%	Unkown
HY-163438	BKIDC-1553	Inhibitor	99.65%	Unkown
HY-17356S	Fenofibrate-d6		99.70%	Unkown
HY-N5132	(-)-Fenchone		98.0%	Unkown
HY-135335S	3'-Hydroxy Repaglinide-d5		99.46%	Unkown
HY-147422	Xininurad	Inhibitor	99.59%	Unkown
HY-N6065	Praeruptorin A		99.57%	Unkown
HY-W754151	N-Desmethyl apalutamide-d4		99.63%	Unkown
HY-124542	5-Hydroxydiclofenac	Inducer	99.52%	Unkown
HY-135810	Cletoquine	Inhibitor	/	Unkown
HY-135810A	Cletoquine oxalate	Inhibitor	99.63%	Unkown
HY-141530	Clopidogrel-β-D-glucuronide	Inhibitor	/	Unkown
HY-117160	4-trans-Hydroxy-glibenclamide	Inhibitor	99.0%	Unkown
HY-125348S	6α-Hydroxy Paclitaxel-d5		99.31%	Unkown
HY-W067374	Aripiprazole impurity 38		97.79%	Unkown
HY-125421	11β-HSD1-IN-26	Inhibitor	/	Unkown
HY-100641S1	4-Hydroxytolbutamide-d9-1		/	Unkown
HY-10575	MK-5596		/	Unkown
HY-135331S	N-Desmethyl-Apalutamide-15N,d4		/	Unkown
HY-135335S1	3'-Hydroxy Repaglinide-d7		/	Unkown
HY-135810S	Cletoquine-d4	Inhibitor	/	Unkown
HY-135810S1	Cletoquine-d4-1	Inhibitor	/	Unkown
HY-155376	mTOR inhibitor-14	Inhibitor	/	Unkown
HY-17356G	Fenofibrate (GMP)		/	Unkown
HY-17356S1	Fenofibrate-d4		/	Unkown
HY-181798	pKal-IN-1	Inhibitor	/	Unkown
HY-183149	BPN-37440	Inhibitor	/	Unkown
HY-183268	TRPM4-IN-4	Inhibitor	/	Unkown
HY-RS03459	CYP2C8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W699866	Gemfibrozil 1-O-β-glucuronide-d6		/	Unkown
HY-W777442	Cletoquine-d4 Oxalate	Inhibitor	/	Unkown
HY-119311	Ketopioglitazone	Agonist	/	Unkown
HY-135334S	ACP-5862-d4	Inhibitor	/	Unkown
HY-17356S2	Fenofibrate-13C6		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CYP2C8	RGD	RGD:1308166
Others	CYP2C8	NCBI