Kcnq2 - potassium voltage-gated channel, subfamily Q, member 2 Gene

Also Known as KQT2; HNSPC; Nmf134

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16536

Summary

Enables Calmodulin binding activity and voltage-gated ion channel activity. Acts upstream of or within membrane hyperpolarization and transmission of nerve impulse. Located in cell surface; main axon; and plasma membrane. Part of voltage-gated Potassium Channel complex. Is expressed in several structures, including brain; gut; immune system; reproductive system; and white fat. Used to study benign neonatal seizures and developmental and epileptic encephalopathy 7. Human ortholog(s) of this gene implicated in benign neonatal seizures and developmental and epileptic encephalopathy 7. Orthologous to human KCNQ2 (potassium voltage-gated channel subfamily Q member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnq2 Products (7)

mRNA Protein Name
NM_001003824.2 NP_001003824.1 potassium voltage-gated channel subfamily KQT member 2 isoform 2
NM_001003825.3 NP_001003825.1 potassium voltage-gated channel subfamily KQT member 2 isoform 3
NM_001006668.2 NP_001006669.1 potassium voltage-gated channel subfamily KQT member 2 isoform 4
NM_001006669.2 NP_001006670.1 potassium voltage-gated channel subfamily KQT member 2 isoform 5
NM_001006674.2 NP_001006675.1 potassium voltage-gated channel subfamily KQT member 2 isoform 6
NM_001302888.1 NP_001289817.1 potassium voltage-gated channel subfamily KQT member 2 isoform 13
NM_010611.3 NP_034741.2 potassium voltage-gated channel subfamily KQT member 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calmodulin binding IMP
IMP: Inferred from mutant phenotype
24333508 MGI
enables calmodulin binding IPI
IPI: Inferred from physical interaction
12223552 MGI
enables potassium channel activity IGI
IGI: Inferred from genetic interaction
23716673 MGI
enables potassium channel activity IMP
IMP: Inferred from mutant phenotype
14762142 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
14762142 MGI
enables voltage-gated monoatomic ion channel activity IGI
IGI: Inferred from genetic interaction
12223552 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within action potential IDA
IDA: Inferred from direct assay
14762142 MGI
acts upstream of or within action potential IMP
IMP: Inferred from mutant phenotype
14762142 MGI
acts upstream of or within action potential initiation IDA
IDA: Inferred from direct assay
26312501 MGI
acts upstream of or within action potential initiation IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within action potential initiation IMP
IMP: Inferred from mutant phenotype
24719109 MGI
acts upstream of or within apoptosome assembly IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within behavior IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
30382937 MGI
acts upstream of or within cellular response to calcium ion IDA
IDA: Inferred from direct assay
23259949 MGI
acts upstream of or within cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
23259949 MGI
acts upstream of or within cognition IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within dentate gyrus development IGI
IGI: Inferred from genetic interaction
16464983 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: Inferred from genetic interaction
21156207 MGI
acts upstream of or within determination of adult lifespan IMP
IMP: Inferred from mutant phenotype
24719109 MGI
acts upstream of or within endocytosis IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within establishment of cell polarity IMP
IMP: Inferred from mutant phenotype
24719109 MGI
acts upstream of or within excitatory chemical synaptic transmission IDA
IDA: Inferred from direct assay
14762142 MGI
acts upstream of or within excitatory chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within exocytosis IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within exploration behavior IMP
IMP: Inferred from mutant phenotype
31283873 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
24333508 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within grooming behavior IMP
IMP: Inferred from mutant phenotype
31283873 MGI
acts upstream of or within hippocampal pyramidal neuron differentiation IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within hippocampus development IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within inhibitory chemical synaptic transmission IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within learning IMP
IMP: Inferred from mutant phenotype
32239694 MGI
acts upstream of or within memory IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within monoatomic ion transmembrane transport IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within motor behavior IMP
IMP: Inferred from mutant phenotype
19453707 MGI
acts upstream of or within nerve development IGI
IGI: Inferred from genetic interaction
16464983 MGI
acts upstream of or within nerve development IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within neuron differentiation IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within neuron remodeling IGI
IGI: Inferred from genetic interaction
30382937 MGI
acts upstream of or within neuronal action potential IMP
IMP: Inferred from mutant phenotype
24719109 MGI
acts upstream of or within protein import into nucleus IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within protein phosphorylation IMP
IMP: Inferred from mutant phenotype
21466805 MGI
acts upstream of or within protein transport IMP
IMP: Inferred from mutant phenotype
20885443 MGI
acts upstream of or within psychomotor behavior IMP
IMP: Inferred from mutant phenotype
19453707 MGI
acts upstream of or within regulation of action potential firing threshold IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within regulation of membrane potential IMP
IMP: Inferred from mutant phenotype
15608631 MGI
acts upstream of or within regulation of synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18483067 MGI
acts upstream of or within response to auditory stimulus IDA
IDA: Inferred from direct assay
26312501 MGI
acts upstream of or within response to auditory stimulus IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
24687876 MGI
acts upstream of or within response to organic cyclic compound IDA
IDA: Inferred from direct assay
20885443 MGI
acts upstream of or within response to temperature stimulus IMP
IMP: Inferred from mutant phenotype
24687876 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
14762142 MGI
acts upstream of or within sensory perception of sound IGI
IGI: Inferred from genetic interaction
23716673 MGI
acts upstream of or within social behavior IMP
IMP: Inferred from mutant phenotype
31283873 MGI
acts upstream of or within sodium ion transmembrane transport IGI
IGI: Inferred from genetic interaction
16464983 MGI
acts upstream of or within substantia propria of cornea development IMP
IMP: Inferred from mutant phenotype
19453707 MGI
acts upstream of or within transmission of nerve impulse IMP
IMP: Inferred from mutant phenotype
10854243 MGI
Cellular Component GO Annotation Evidence References Source
is active in axon initial segment IDA
IDA: Inferred from direct assay
14762142 MGI
located in axon initial segment IDA
IDA: Inferred from direct assay
16525039 MGI
located in cell surface IDA
IDA: Inferred from direct assay
12223552 MGI
is active in node of Ranvier IDA
IDA: Inferred from direct assay
14762142 MGI
located in node of Ranvier IDA
IDA: Inferred from direct assay
16525039 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
16525039 MGI
part of voltage-gated potassium channel complex IGI
IGI: Inferred from genetic interaction
12223552 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily KQT member 2

  • KQT-like 2

  • potassium channel subunit alpha KvLQT2

  • voltage-gated potassium channel subunit Kv7.2

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1281 Mepyramine maleate 99.94% Unkown

Pre-clinical Phase

Bioactive Molecules (27)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-108577 XE991 dihydrochloride Inhibitor / Unkown
HY-122114 ICA-27243 Activator 98.74% Unkown
HY-108577A XE991 Inhibitor 99.69% Unkown
HY-18063 ML252 Inhibitor 99.9% Unkown
HY-113616A VU0364572 TFA Agonist 98.79% Unkown
HY-101396 ICA-069673 Activator 99.20% Unkown
HY-108587 ICA 110381 Modulator 99.80% Unkown
HY-157485 Ebio1 Activator 99.99% Unkown
HY-108592 UCL 2077 Inhibitor 98.91% Unkown
HY-145016 HN37 Activator 99.53% Unkown
HY-123264 RL648_81 Inhibitor 99.49% Unkown
HY-181128 QO-83 Activator 99.58% Unkown
HY-18063A ML252 hydrochloride Inhibitor 98.5% Unkown
HY-113616 VU0364572 Agonist / Unkown
HY-118807A Mepyramine hydrochloride / Unkown
HY-118807S Mepyramine-d2 / Unkown
HY-130070 QO-40 Activator 98.77% Unkown
HY-168214 Kv7.2/Kv7.3 agonist 1 Inhibitor / Unkown
HY-172140 Ebio3 Inhibitor / Unkown
HY-172141 Ebio2 Activator / Unkown
HY-182435 CLE-030 Agonist / Unkown
HY-184207 Zinc13732787 Inhibitor / Unkown
HY-RS07174 KCNQ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-115823 ztz240 99.94% Unkown
HY-180873 KCNQ2 modulator-1 / Unkown
HY-RS17110 Kcnq2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23555 Kcnq2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnq2 NCBI NCBI:3785