Havcr1 - hepatitis A virus cellular receptor 1 Gene

Also Known as Tim1; KIM-1; TIM-1; Timd1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 171283

Summary

Enables phosphatidylserine binding activity. Acts upstream of or within positive regulation of mast cell activation; response to lipopolysaccharide; and response to wounding. Located in brush border and cell surface. Is expressed in brain; dorsal aorta; liver; lung; and reproductive system. Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Havcr1 Products (3)

mRNA Protein Name
NM_001166631.1 NP_001160103.1 hepatitis A virus cellular receptor 1 homolog isoform b precursor
NM_001166632.1 NP_001160104.1 hepatitis A virus cellular receptor 1 homolog isoform b precursor
NM_134248.2 NP_599009.2 hepatitis A virus cellular receptor 1 homolog isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phosphatidylserine binding IDA
IDA: Inferred from direct assay
18083575 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15793576 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of mast cell activation IDA
IDA: Inferred from direct assay
20566714 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: Inferred from direct assay
29402223 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
29402223 MGI
Cellular Component GO Annotation Evidence References Source
located in brush border IDA
IDA: Inferred from direct assay
29402223 MGI
located in cell surface IDA
IDA: Inferred from direct assay
18083575 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatitis A virus cellular receptor 1 homolog

  • HAVcr-1

  • T-cell immunoglobulin and mucin domain containing 1

  • T-cell immunoglobulin mucin receptor 1

  • TIMD-1

  • kidney injury molecule 1

  • t cell immunoglobulin and mucin domain-containing protein 1

  • t cell membrane protein 1

Havcr1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Havcr1 Q5QNS5 Timd4 Mus musculus Q6U7R4
FACS
15793576
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant Havcr1 Proteins

Cat. No. Product Name Accession Purity
HY-P71365 TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) Q5QNS5-1 (Y22-T212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06021 HAVCR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19510 Havcr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26004 Havcr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Havcr1 NCBI NCBI:26762