TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His)

The TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that is critical for B cell homeostasis, affecting generation, expansion, and inhibitory functions. As a P-selectin/SELPLG ligand, it facilitates trafficking of activated T cells during inflammation and controls T cell accumulation in the inflamed central nervous system. TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-6*His labeled tag.

TIM-1/KIM-1/HAVCR Protein is a phosphatidylserine receptor that plays a crucial role in regulating B-cell homeostasis, including their generation, expansion, and suppressor functions. It functions as a P-selectin/SELPLG ligand, facilitating the trafficking of activated T-cells during inflammatory responses. This protein is involved in controlling T-cell accumulation in the inflamed central nervous system (CNS) and the development of autoimmune diseases. It also regulates the expression of several anti-inflammatory cytokines and co-inhibitory ligands, such as IL10. Additionally, TIM-1/KIM-1/HAVCR Protein acts as a regulator of T-cell proliferation and may have a role in kidney injury and repair. It interacts with STAM and SELPLG.

Mouse

HEK293

C-6*His

Q5QNS5-1 (Y22-T212)

171283  [NCBI]

Partial

YVEVKGVVGHPVTLPCTYSTYRGITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDSGLYCCRVEIPGWFNDQKVTFSLQVKPEIPTRPPTRPTTTRPTATGRPTTISTRSTHVPTSIRVSTSTPPTSTHTWTHKPEPTTFCPHETTAEVTGIPSHTPTDWNGTVT

35-50 kDa

≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US;may vary elsewhere.