TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His)
Based on 1 Customer Validation
The TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that is critical for B cell homeostasis, affecting generation, expansion, and inhibitory functions. As a P-selectin/SELPLG ligand, it facilitates trafficking of activated T cells during inflammation and controls T cell accumulation in the inflamed central nervous system. TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-6*His labeled tag.
- Species: Mouse
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
The TIM-1/KIM-1/HAVCR protein is a phosphatidylserine receptor that is critical for B cell homeostasis, affecting generation, expansion, and inhibitory functions. As a P-selectin/SELPLG ligand, it facilitates trafficking of activated T cells during inflammation and controls T cell accumulation in the inflamed central nervous system. TIM-1/KIM-1/HAVCR Protein, Mouse (HEK293, C-His) is the recombinant mouse-derived TIM-1/KIM-1/HAVCR protein, expressed by HEK293 , with C-6*His labeled tag.
TIM-1/KIM-1/HAVCR Protein is a phosphatidylserine receptor that plays a crucial role in regulating B-cell homeostasis, including their generation, expansion, and suppressor functions. It functions as a P-selectin/SELPLG ligand, facilitating the trafficking of activated T-cells during inflammatory responses. This protein is involved in controlling T-cell accumulation in the inflamed central nervous system (CNS) and the development of autoimmune diseases. It also regulates the expression of several anti-inflammatory cytokines and co-inhibitory ligands, such as IL10. Additionally, TIM-1/KIM-1/HAVCR Protein acts as a regulator of T-cell proliferation and may have a role in kidney injury and repair. It interacts with STAM and SELPLG.
Technical Parameters
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Species Mouse
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Source HEK293
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Tag C-6*His
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Accession
Q5QNS5-1 (Y22-T212)
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Molecular Construction
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N-term
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TIM-1 (Y22-T212)
Accession # Q5QNS5-1 -
6*His
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C-term
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Protein Length
Partial
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Synonyms
HAVCR1; T-Cell Membrane Protein 1; Hepatitis A Virus Cellular Receptor 1; TIMD-1; TIM-1; KIM-1; TIMD1; TIM; TIM1; T-Cell Immunoglobulin And Mucin Domain-Containing Protein 1; KIM1; T Cell Immunoglobin Domain And Mucin Domain Protein 1; Kidney Injury Molec
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AA Sequence
YVEVKGVVGHPVTLPCTYSTYRGITTTCWGRGQCPSSACQNTLIWTNGHRVTYQKSSRYNLKGHISEGDVSLTIENSVESDSGLYCCRVEIPGWFNDQKVTFSLQVKPEIPTRPPTRPTTTRPTATGRPTTISTRSTHVPTSIRVSTSTPPTSTHTWTHKPEPTTFCPHETTAEVTGIPSHTPTDWNGTVT
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Predicted Molecular Mass
21.8 kDa
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Molecular Weight
Approximately 35-50 kDa, based on SDS-PAGE under reducing conditions.
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Glycosylation
Yes
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
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Data Sheet (236 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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