Mt1 - metallothionein 1 Gene

Also Known as MT-I; Mt-1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 17748

Summary

Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and cellular zinc ion homeostasis. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and nasal cavity epithelium. Orthologous to several human genes including MT1A (metallothionein 1A); MT1E (metallothionein 1E); and MT1F (metallothionein 1F). [provided by Alliance of Genome Resources, Apr 2022]

Mt1 Products (1)

mRNA Protein Name
NM_013602.3 NP_038630.1 metallothionein-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables copper ion binding IDA
IDA: Inferred from direct assay
9358851 MGI
enables metal ion binding IDA
IDA: Inferred from direct assay
12130647 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular response to chromate IDA
IDA: Inferred from direct assay
18605988 MGI
acts upstream of or within cellular response to zinc ion IDA
IDA: Inferred from direct assay
18605988 MGI
acts upstream of or within detoxification of copper ion IGI
IGI: Inferred from genetic interaction
8640230 MGI
acts upstream of or within intracellular monoatomic cation homeostasis IDA
IDA: Inferred from direct assay
12130647 MGI
acts upstream of or within intracellular zinc ion homeostasis IMP
IMP: Inferred from mutant phenotype
11792622 MGI
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
21359432 MGI
acts upstream of or within nitric oxide mediated signal transduction IMP
IMP: Inferred from mutant phenotype
11792622 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
9358851 MGI
located in lysosome IDA
IDA: Inferred from direct assay
9358851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

metallothionein-1

  • metallothionein-I

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-A0014 Ramelteon Agonist 99.85% Yes

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-105285 Piromelatine Agonist 99.70% Phase 3
HY-106136 TIK-301 Agonist / Phase 2

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-114962 S-22153 Antagonist 99.94% Unkown
HY-101176 2-Iodomelatonin Agonist 99.04% Unkown
HY-138626 ACH-000143 Agonist 98.58% Unkown
HY-101074 UCM 608 Agonist 99.18% Unkown
HY-17038S Agomelatine-d6 Agonist 99.05% Unkown
HY-A0014S Ramelteon-d5 Agonist 99.83% Unkown
HY-17038S2 Agomelatine-d3 Agonist 98.0% Unkown
HY-107628 N-Pentanoyl 2-benzyltryptamine Antagonist 99.0% Unkown
HY-17038S1 Agomelatine-d4 Agonist / Unkown
HY-180198 UCM1400 / Unkown
HY-100940 6-Chloromelatonin Agonist / Unkown
HY-147542 Melatonin receptor agonist 1 Agonist / Unkown
HY-133112 7-Desmethyl-3-hydroxyagomelatine Agonist / Unkown
HY-131947 DH97-7 Antagonist / Unkown
HY-115304 UCM 793 Agonist / Unkown