Mt1 - metallothionein 1 Gene

Mus musculus

Also known as MT-I; Mt-1

Gene ID: 17748 | Gene type: protein coding

About Mt1

Summary

Enables copper ion binding activity. Involved in negative regulation of neuron apoptotic process. Acts upstream of or within several processes, including cellular response to chromate; cellular response to zinc ion; and cellular zinc ion homeostasis. Located in cytosol and lysosome. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; liver; and nasal cavity epithelium. Orthologous to several human genes including MT1A (metallothionein 1A); MT1E (metallothionein 1E); and MT1F (metallothionein 1F). [provided by Alliance of Genome Resources, Apr 2022]

Mt1 Products(1)

mRNA	Protein	Name
NM_013602.3	NP_038630.1	metallothionein-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper ion binding	IDA IDA: Inferred from direct assay	9358851	MGI
enables metal ion binding	IDA IDA: Inferred from direct assay	12130647	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cellular response to chromate	IDA IDA: Inferred from direct assay	18605988	MGI
acts upstream of or within cellular response to zinc ion	IDA IDA: Inferred from direct assay	18605988	MGI
acts upstream of or within detoxification of copper ion	IGI IGI: Inferred from genetic interaction	8640230	MGI
acts upstream of or within intracellular monoatomic cation homeostasis	IDA IDA: Inferred from direct assay	12130647	MGI
acts upstream of or within intracellular zinc ion homeostasis	IMP IMP: Inferred from mutant phenotype	11792622	MGI
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	21359432	MGI
acts upstream of or within nitric oxide mediated signal transduction	IMP IMP: Inferred from mutant phenotype	11792622	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	9358851	MGI
located in lysosome	IDA IDA: Inferred from direct assay	9358851	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

metallothionein-1

metallothionein-I

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-A0014	Ramelteon	Agonist	99.85%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105285	Piromelatine	Agonist	99.70%	Phase 3
HY-106136	TIK-301	Agonist	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (15)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114962	S-22153	Antagonist	99.94%	Unkown
HY-101176	2-Iodomelatonin	Agonist	99.04%	Unkown
HY-138626	ACH-000143	Agonist	98.58%	Unkown
HY-101074	UCM 608	Agonist	99.18%	Unkown
HY-17038S	Agomelatine-d6	Agonist	98.57%	Unkown
HY-A0014S	Ramelteon-d5	Agonist	99.83%	Unkown
HY-17038S2	Agomelatine-d3	Agonist	98.0%	Unkown
HY-107628	N-Pentanoyl 2-benzyltryptamine	Antagonist	99.0%	Unkown
HY-17038S1	Agomelatine-d4	Agonist	/	Unkown
HY-180198	UCM1400		/	Unkown
HY-100940	6-Chloromelatonin	Agonist	/	Unkown
HY-147542	Melatonin receptor agonist 1	Agonist	/	Unkown
HY-133112	7-Desmethyl-3-hydroxyagomelatine	Agonist	/	Unkown
HY-131947	DH97-7	Antagonist	/	Unkown
HY-115304	UCM 793	Agonist	/	Unkown

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