ALDOA - aldolase, fructose-bisphosphate A Gene

Homo sapiens

Also known as ALDA; GSD12; HEL-S-87p

Gene ID: 226 | Gene type: protein coding

About ALDOA

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:30,064,279-30,070,420 (from NCBI)

This gene has 19 transcripts (splice variants), 266 orthologues, 2 paralogues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 290.3), esophagus (RPKM 221.3) and 25 other tissues.

Summary

This gene encodes a member of the class I fructose-bisphosphate aldolase protein family. The encoded protein is a glycolytic Enzyme that catalyzes the reversible conversion of fructose-1,6-bisphosphate to glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. Three aldolase isozymes (A, B, and C), encoded by three different genes, are differentially expressed during development. Mutations in this gene have been associated with Glycogen Storage Disease XII, an autosomal recessive disorder associated with hemolytic anemia. Disruption of this gene also plays a role in the progression of multiple types of cancers. Related pseudogenes have been identified on chromosomes 3 and 10. [provided by RefSeq, Sep 2017]

ALDOA Products(4)

mRNA	Protein	Name
NM_001127617.2	NP_001121089.1	fructose-bisphosphate aldolase A isoform 1
NM_001243177.4	NP_001230106.1	fructose-bisphosphate aldolase A isoform 2
NM_184041.5	NP_908930.1	fructose-bisphosphate aldolase A isoform 1
NM_184043.2	NP_908932.1	fructose-bisphosphate aldolase A isoform 1

ALDOA Protein Structure

Glycolytic

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

fructose-bisphosphate aldolase A

aldolase A, fructose-bisphosphate

Recombinant ALDOA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7877	Fructose-bisphosphate aldolase A/ALDOA Protein, Human (C-His)	P04075 (P2-Y364)	≥95%
HY-P700265	Fructose-bisphosphate aldolase A/ALDOA Protein, Human (364aa, His)	P04075 (P2-Y364)	≥95%

Related Diseases

Diseases

Alias

Glycogen Storage Disease Xii

Aldolase A Deficiency	Red Cell Aldolase Deficiency
GSD12	Aldoa Deficiency
Gsd Xii	Glycogen Storage Disease Type 12
Glycogen Storage Disease 12	Aldolase Deficiency, Red Cell
Aldolase Deficiency Red Cell	Glycogen Storage Disease Due To Aldolase A Deficiency
Gsd Due To Aldolase A Deficiency	Gsd Type 12
Gsd Type Xii	Glycogen Storage Disease Type Xii
Glycogenosis Due To Aldolase A Deficiency	Glycogenosis Type 12
Glycogenosis Type Xii	Storage Disease, Glycogen, Type Xii

Hemolytic Anemia

Anemia, Hemolytic	Anemia Hemolytic
Anaemia Due To Other Disorders Of Glutathione Metabolism	Chronic Non Spherocytic Anaemia
G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia	Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency
Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia	Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia
Favism Anaemia	Haemolytic Anaemia Due Tog6pd Deficiency
Favism	Pentose Phosphate Pathway Disorder Anaemia
Anaemia Due To Pentose Phosphate Pathway Defect

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Myopathy

Muscular Diseases

Myopathies

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Urinary System Disease

Abnormality Of The Urinary System	Non-Neoplastic Urinary Tract Disease
Urinary Tract Disease	Urinary Tract Diseases
Urinary Tract Anomaly	Urologic Diseases
Non-Neoplastic Urinary System Disorder	Congenital Malformation Of The Urinary System

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00583	ALDOA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ALDOA	VGNC	VGNC:107737
Macaca mulatta	ALDOA	VGNC	VGNC:103785
Bos taurus	ALDOA	VGNC	VGNC:25821
Rattus norvegicus	ALDOA	RGD	RGD:2089
Mus musculus	ALDOA	MGD	MGI:87994
Others	ALDOA	NCBI

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