Gpr158 - G protein-coupled receptor 158 Gene

Also Known as mKIAA1136; 5330427M13Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 241263

Summary

Predicted to enable G protein-coupled receptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Located in membrane. Is expressed in eye; male reproductive gland or organ; nervous system; and small intestine. Orthologous to human GPR158 (G protein-coupled receptor 158). [provided by Alliance of Genome Resources, Apr 2022]

Gpr158 Products (1)

mRNA	Protein	Name
NM_001004761.1	NP_001004761.1	probable G-protein coupled receptor 158 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	25792749	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	22689652	MGI
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	28851741	MGI
enables transmembrane signaling receptor activity	IMP IMP: Inferred from mutant phenotype	25792749	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22689652	MGI
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	25792749	MGI
acts upstream of or within G protein-coupled receptor signaling pathway	IGI IGI: Inferred from genetic interaction	22689652	MGI
involved in brain development	IDA IDA: Inferred from direct assay	28851741	MGI
involved in cognition	IDA IDA: Inferred from direct assay	28851741	MGI
involved in cognition	IMP IMP: Inferred from mutant phenotype	25792749	MGI
involved in positive regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	28851741	MGI
acts upstream of or within protein localization to plasma membrane	IDA IDA: Inferred from direct assay	22689652	MGI
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	25792749	MGI
involved in regulation of synapse organization	IDA IDA: Inferred from direct assay	25792749	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	22689652	MGI
is active in plasma membrane	IDA IDA: Inferred from direct assay	30546127	MGI
is active in postsynaptic density membrane	IDA IDA: Inferred from direct assay	30290982	MGI
is active in postsynaptic density membrane	IEP IEP: Inferred from expression pattern	30290982	MGI
is active in postsynaptic density membrane	IMP IMP: Inferred from mutant phenotype	30290982	MGI
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	30290982	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
probable G-protein coupled receptor 158

Gpr158 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	Gpr158	Q8C419	GPC5	Homo sapiens	P78333	Anti Tag CoIP	30282023
Cross	Gpr158	Q8C419	SDC4	Homo sapiens	P31431	Anti Tag CoIP	30282023
Cross	Gpr158	Q8C419	SDC4	Homo sapiens	P31431	Pull Down	30282023
Cross	Gpr158	Q8C419	GPC1	Homo sapiens	P35052	Pull Down	30282023
Cross	Gpr158	Q8C419	GPC1	Homo sapiens	P35052	Anti Tag CoIP	30282023

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05675	GPR158 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19507	Gpr158 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26001	Gpr158 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gpr158	NCBI	NCBI:57512