Atp1a2 - ATPase Na+/K+ transporting subunit alpha 2 Gene

Also Known as RATATPA2

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 24212

Summary

Enables several functions, including ATP binding activity; P-type sodium:potassium-exchanging transporter activity; and protein heterodimerization activity. Involved in several processes, including cation transport; cellular response to mechanical stimulus; and negative regulation of calcium:sodium antiporter activity. Located in several cellular components, including T-tubule; caveola; and intercalated disc. Part of sodium:potassium-exchanging ATPase complex. Biomarker of hyperhomocysteinemia and hypertension. Human ortholog(s) of this gene implicated in alternating hemiplegia of childhood; benign neonatal seizures; familial hemiplegic migraine 2; hypertension; and migraine with aura. Orthologous to human ATP1A2 (ATPase Na+/K+ transporting subunit alpha 2). [provided by Alliance of Genome Resources, Apr 2022]

Atp1a2 Products (1)

mRNA	Protein	Name
NM_012505.2	NP_036637.1	sodium/potassium-transporting ATPase subunit alpha-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	12529322	RGD
enables ATPase-coupled monoatomic cation transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	12529322	RGD
enables P-type sodium:potassium-exchanging transporter activity	IDA IDA: Inferred from direct assay	16624992	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12093728	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	28787093	RGD
enables steroid hormone binding	IDA IDA: Inferred from direct assay	17442282	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	17458903	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16893515	RGD
involved in cellular response to steroid hormone stimulus	IMP IMP: Inferred from mutant phenotype	17442282	RGD
involved in negative regulation of calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	17442282	RGD
involved in negative regulation of calcium:sodium antiporter activity	IMP IMP: Inferred from mutant phenotype	17442282	RGD
involved in potassium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD
involved in proton transmembrane transport	IMP IMP: Inferred from mutant phenotype	12529322	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	17442282	RGD
involved in response to glycoside	IMP IMP: Inferred from mutant phenotype	17442282	RGD
involved in response to nicotine	IDA IDA: Inferred from direct assay	22442718	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	12093728	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in T-tubule	IDA IDA: Inferred from direct assay	17442282	RGD
located in caveola	IDA IDA: Inferred from direct assay	16624992	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	11950769	RGD
located in endosome	IDA IDA: Inferred from direct assay	16893515	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	17442282	RGD
located in membrane	IDA IDA: Inferred from direct assay	28787093	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	17442282	RGD
part of sodium:potassium-exchanging ATPase complex	IDA IDA: Inferred from direct assay	12093728	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
sodium/potassium-transporting ATPase subunit alpha-2	ATPase, Na+/K+ transporting, alpha 2 polypeptide ATPase, Na+K+ transporting, alpha 2 Na(+)/K(+) ATPase alpha(+) subunit Na(+)/K(+) ATPase alpha-2 subunit Na+/K+ -ATPase alpha 2 subunit sodium pump subunit alpha-2

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01183	ATP1A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS01187	ATP1B2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21822	Atp1a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21823	Atp1b2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28339	Atp1a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp1a2	NCBI	NCBI:477