ENO2 - Eno2 enolase 2 Gene

Also Known as NSE; RNEN3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24334

Summary

Enables enzyme binding activity; identical protein binding activity; and phosphopyruvate hydratase activity. Involved in several processes, including glucose metabolic process; negative regulation of neuron death; and response to estradiol. Located in several cellular components, including growth cone; membrane raft; and synaptic membrane. Part of phosphopyruvate hydratase complex. Biomarker of Parkinsonism; toxic shock syndrome; and visual epilepsy. Human ortholog(s) of this gene implicated in prostate Cancer. Orthologous to human ENO2 (Enolase 2). [provided by Alliance of Genome Resources, Apr 2022]

ENO2 Products (1)

mRNA Protein Name
NM_139325.4 NP_647541.1 gamma-enolase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
14499952 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
990313 RGD
enables phosphopyruvate hydratase activity IDA
IDA: Inferred from direct assay
7964722 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
990313 RGD
Biological Process GO Annotation Evidence References Source
involved in canonical glycolysis IDA
IDA: Inferred from direct assay
15041191 RGD
involved in gluconeogenesis IDA
IDA: Inferred from direct assay
15720133 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16689882 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15856951 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
18289475 RGD
Cellular Component GO Annotation Evidence References Source
located in cell cortex IDA
IDA: Inferred from direct assay
19433310 RGD
located in cell surface IDA
IDA: Inferred from direct assay
14499952 RGD
located in growth cone IDA
IDA: Inferred from direct assay
19433310 RGD
located in membrane raft IDA
IDA: Inferred from direct assay
14499952 RGD
part of phosphopyruvate hydratase complex IDA
IDA: Inferred from direct assay
15041191 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
15041191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

gamma-enolase

  • 2-phospho-D-glycerate hydro-lyase

  • enolase 2, gamma, neuronal

  • gamma-enolase-like

  • neural enolase

  • neuron-specific enolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-131904 POMHEX 99.54% Unkown
HY-N0563 Alizarin 99.48% Unkown
HY-117778 SF2312 Inhibitor 95.0% Unkown
HY-131904A Hex Inhibitor 99.62% Unkown
HY-RS04379 ENO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17161 Eno2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23611 Eno2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ENO2 NCBI NCBI:2026