Spink1 - serine peptidase inhibitor, Kazal type 1 Gene

Also Known as Tilp; Psti-1; Spink3; PSTI-61

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24833

Summary

Enables serine-type endopeptidase inhibitor activity. Involved in several processes, including negative regulation of serine-type endopeptidase activity; positive regulation of secretion; and response to ethanol. Located in cytoplasm and extracellular space. Human ortholog(s) of this gene implicated in pancreatitis. Orthologous to human SPINK1 (serine peptidase inhibitor Kazal type 1). [provided by Alliance of Genome Resources, Apr 2022]

Spink1 Products (1)

mRNA Protein Name
NM_012674.2 NP_036806.1 serine protease inhibitor Kazal-type 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables serine-type endopeptidase inhibitor activity IDA
IDA: Inferred from direct assay
12771515 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
1379547 RGD
involved in negative regulation of serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
12771515 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: Inferred from direct assay
1594624 RGD
involved in positive regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
9693203 RGD
involved in positive regulation of pancreatic juice secretion IDA
IDA: Inferred from direct assay
2755938 RGD
involved in positive regulation of peptide hormone secretion IDA
IDA: Inferred from direct assay
2755938 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
11484913 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
2065678 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
7526044 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine protease inhibitor Kazal-type 1

  • PSTI-I

  • Serine protease inhibitor, kanzal type 1/ Trypsin inhibitor-like protein, pancreatic

  • cholecystokinin-releasing peptide

  • monitor peptide

  • pancreatic cholecystokinin(CCK) releasing peptide

  • pancreatic secretory trypsin inhibitor I

  • pancreatic secre

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13679 SPINK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19269 Spink1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25758 Spink1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Spink1 NCBI NCBI:6690