SPINK1 - serine peptidase inhibitor Kazal type 1 Gene

Also Known as TCP; PCTT; PSTI; TATI; Spink3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6690

About SPINK1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:147,824,582-147,839,196 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues and is associated with 5 phenotypes. Biased expression in pancreas (RPKM 2401.2), stomach (RPKM 337.4) and 2 other tissues.

Summary

The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis. [provided by RefSeq, Oct 2008]

SPINK1 Products (3)

mRNA	Protein	Name
NM_001354966.2	NP_001341895.1	serine protease inhibitor Kazal-type 1 precursor
NM_001379610.1	NP_001366539.1	serine protease inhibitor Kazal-type 1 precursor
NM_003122.5	NP_003113.2	serine protease inhibitor Kazal-type 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14507909	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPINK1 Protein Structure

Kazal_1

0
79 a.a.

Protein Preferred Names	Protein Names
serine protease inhibitor Kazal-type 1	pancreatic secretory trypsin inhibitor

SPINK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SPINK1	P00995	ASPH	Homo sapiens	Q12797-6	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SPINK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71053	SPINK1 Protein, Human (HEK293, His)	P00995 (D24-C79)	≥ 95%, as determined by reducing SDS-PAGE.

SPINK1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81459	SPINK1 Antibody (YA1204)	IHC-P	Human
HY-P81459A	SPINK1 Antibody (YA1204)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Tropical Calcific Pancreatitis	Tropical Pancreatitis TCP Fibrocalculous Pancreatic Diabetes Tropical Calcific Chronic Pancreatitis Fibrocalculous Pancreatic Diabetes, Susceptibility To Tcp - [Tropical Chronic Pancreatitis]
Pancreatitis, Hereditary	Hereditary Pancreatitis Chronic Pancreatitis Hereditary Chronic Pancreatitis Hp Pancreatitis, Chronic, Susceptibility To PCTT Hpc Pancreatitis, Chronic Pancreatitis, Chronic, Protection Against Autosomal Dominant Hereditary Pancreatitis Familial Pancreatitis Cp Pancreatitis Hereditary
Prss1-Related Hereditary Pancreatitis
Diabetes Mellitus	Diabetes
Pancreatitis	Mumps Pancreatitis
Alcoholic Pancreatitis	Pancreatitis, Alcoholic Pancreatitis Alcoholic
Parotitis
Acute Pancreatitis	Pancreatitis Pancreatitis, Acute Necrotizing Pancreatitis Nos Acute Pancreas Inflammation
Pancreas Disease	Abnormality Of The Pancreas Pancreatic Diseases
Exocrine Pancreatic Insufficiency
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis
Pancreas, Annular	Annular Pancreas Pancreas Annulare Congenital Annular Pancreas
Acute Hemorrhagic Pancreatitis	Pancreatitis, Acute Hemorrhagic
Biliary Dyskinesia	Sphincter Of Oddi Dysfunction
Autoimmune Pancreatitis	Lymphoplasmocytic Sclerosing Pancreatitis Aip
Parkinson Disease 8, Autosomal Dominant	Parkinson Disease 8 Autosomal Dominant Parkinson Disease 8 PARK8 Parkinson'S Disease 8 Autosomal Dominant Parkinson'S Disease 8 Parkinson Disease-8 Parkinson Disease, Type 8, Autosomal Dominant
Cervical Adenocarcinoma	Adenocarcinoma Cervix Uteri Adenocarcinoma Of Cervix Adenocarcinoma Of The Uterine Cervix Adenocarcinoma Of The Cervix Uteri
Transitional Cell Carcinoma	Transitional Cell Neoplasm Carcinoma, Transitional Cell Transitional Carcinoma Transitional Cell Tumor Urothelial Cell Carcinoma Carcinoma Transitional Cell Transitional Cell Carcinoma Of Bladder
Duodenal Obstruction
Citrullinemia, Type Ii, Adult-Onset	Citrin Deficiency CTLN2 Citrullinemia Type Ii Adult-Onset Citrullinemia Type 2 Adult-Onset Type Ii Citrullinemia Citrullinemia, Adult-Onset Type Ii Adult-Onset Citrin Deficiency Adult-Onset Citrullinemia Type Ii Citrullinemia Type 2 Citrullinemia 2 Citrullinemia, Type Ii
Dysplastic Nevus Syndrome	Familial Atypical Multiple Mole-Melanoma Familial Atypical Multiple Mole Melanoma Syndrome Melanoma-Pancreatic Cancer Syndrome Famm Syndrome B-K Mole Syndrome Famm-Pc Syndrome Fammm Syndrome Familial Atypical Mole Syndrome Familial Atypical Multiple Mole Melanoma-Pancreatic Carcinoma Syndrome Familial Dysplastic Nevus Syndrome Familial Atypical Multiple Mole Melanoma Dysplastic Nevus Familial Atypical Mole Melanoma Syndrome
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Mikulicz Disease	Igg4-Related Dacryoadenitis And Sialadenitis Mikulicz'S Disease Chronic Dacryoadenitis And Sialadenitis Mikulicz Syndrome Mikulicz' Disease
Branchiootorenal Syndrome 2	BOR2 Bor Syndrome 2 Branchiootorenal Dysplasia 2 Branchio-Oto-Renal Dysplasia 2 Branchio-Oto-Renal Syndrome Type 2 Branchiootorenal Syndrome, Type 2
Bile Duct Cysts	Choledochal Cyst Choledochal Cysts Choledochocele Biliary Cyst Congenital Choledochal Cyst Bile Duct Cyst Congenital Cystic Dilatation Of The Biliary Tract Congenital Bile Duct Dilatation
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Common Bile Duct Disease	Common Bile Duct Diseases
Arthrogryposis, Distal, Type 1c	DA1C Distal Arthrogryposis Type 1c Arthrogryposis, Distal, 1c
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Citrullinemia, Classic	Citrullinemia Classic Citrullinemia Argininosuccinate Synthetase Deficiency Ass Deficiency Citrullinemia Type I CTLN1 Citrullinuria Citrullinemia, Type I Argininosuccinic Acid Synthetase Deficiency Ctnl1 Citrullinemia 1 Deficiency Of Citrulline-Aspartate Ligase Cit Argininosuccinate Synthase Deficiency Argininosuccinic Acid Synthase Deficiency Citrullinemia Type 1 Citrullinemia Classical
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Lactic Acidosis	Acidosis, Lactic Acidosis Lactic
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Lynch Syndrome	Hereditary Nonpolyposis Colon Cancer Hereditary Nonpolyposis Colorectal Cancer Hereditary Nonpolyposis Colorectal Carcinoma Hereditary Nonpolyposis Colorectal Neoplasms Familial Nonpolyposis Colon Cancer Hnpcc Coca 1 Hereditary Defective Mismatch Repair Syndrome Hereditary Non-Polyposis Colon Cancer Hereditary Non-Polyposis Colon Cancer Syndrome Hereditary Non-Polyposis Colorectal Cancer Hereditary Non-Polyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colon Cancer Syndrome Hereditary Nonpolyposis Colorectal Cancer Syndrome Hereditary Nonpolyposis Colorectal Neoplasm Hnpcc - Hereditary Nonpolyposis Colon Cancer Cancer Family Syndrome Familial Nonpolyposis Colorectal Cancer Colon Cancer, Familial Nonpolyposis Colorectal Neoplasms, Hereditary Nonpolyposis Cancer, Colorectal, Nonpolyposis, Hereditary Colorectal Cancer, Hereditary Nonpolyposis, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13679	SPINK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19269	Spink1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25758	Spink1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SPINK1	VGNC	VGNC:53474
Rattus norvegicus	SPINK1	RGD	RGD:3749
Mus musculus	SPINK1	MGD	MGI:106202
Macaca mulatta	SPINK1	VGNC	VGNC:77860
Bos taurus	SPINK1	VGNC	VGNC:35219
Others	SPINK1	NCBI