Ntrk2 - neurotrophic receptor tyrosine kinase 2 Gene

Also Known as Tkrb; trkB; TRKB1; trk-B; RATTRKB1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25054

About Ntrk2

Primary_assembly 17: 5,559,043-5,869,136 reverse strand.mRatBN7.2:CM026990.1

This gene has 5 transcripts (splice variants), 288 orthologues, 54 paralogues and is associated with 42 phenotypes. Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues.

Summary

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk2 Products (2)

mRNA Protein Name
NM_001163168.3 NP_001156640.1 BDNF/NT-3 growth factors receptor isoform 2 precursor
NM_012731.3 NP_036863.1 BDNF/NT-3 growth factors receptor isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables brain-derived neurotrophic factor binding IDA
IDA: Inferred from direct assay
1645620 RGD
enables brain-derived neurotrophic factor binding IMP
IMP: Inferred from mutant phenotype
16983663 RGD
enables brain-derived neurotrophic factor receptor activity IDA
IDA: Inferred from direct assay
1645620 RGD
enables neurotrophin binding IDA
IDA: Inferred from direct assay
1645620 RGD
enables neurotrophin receptor activity IDA
IDA: Inferred from direct assay
16477614 RGD
enables neurotrophin receptor activity IMP
IMP: Inferred from mutant phenotype
16983663 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9582017 RGD
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
8627351 RGD
enables receptor tyrosine kinase binding IPI
IPI: Inferred from physical interaction
16801538 RGD
enables transmembrane receptor protein tyrosine kinase activity IMP
IMP: Inferred from mutant phenotype
17447135 RGD
Biological Process GO Annotation Evidence References Source
involved in brain-derived neurotrophic factor receptor signaling pathway IDA
IDA: Inferred from direct assay
1645620 RGD
involved in brain-derived neurotrophic factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
15654844 RGD
involved in cellular response to brain-derived neurotrophic factor stimulus IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
21958434 RGD
involved in long-term memory IDA
IDA: Inferred from direct assay
21136519 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
10985347 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
10985347 RGD
involved in positive regulation of axonogenesis IMP
IMP: Inferred from mutant phenotype
10985347 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
9582017 RGD
acts upstream of or within positive regulation of glucocorticoid receptor signaling pathway IGI
IGI: Inferred from genetic interaction
23878391 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
10985347 RGD
involved in positive regulation of synaptic transmission, glutamatergic IMP
IMP: Inferred from mutant phenotype
16983663 RGD
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
9582017 RGD
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
17447135 RGD
involved in regulation of MAPK cascade IDA
IDA: Inferred from direct assay
9582017 RGD
involved in regulation of dendrite development IMP
IMP: Inferred from mutant phenotype
15654844 RGD
involved in regulation of neurotransmitter secretion IDA
IDA: Inferred from direct assay
16477614 RGD
involved in response to auditory stimulus IEP
IEP: Inferred from expression pattern
21034795 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
18322102 RGD
involved in response to light stimulus IEP
IEP: Inferred from expression pattern
17640634 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
17079678 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
18582438 RGD
located in cell surface IDA
IDA: Inferred from direct assay
17079678 RGD
located in dendrite IDA
IDA: Inferred from direct assay
17079678 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
18582438 RGD
located in excitatory synapse IDA
IDA: Inferred from direct assay
17079678 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
10679783 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
25632160 RGD
located in growth cone IDA
IDA: Inferred from direct assay
17079678 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
17079678 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16626872 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
21775604 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
1645620 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
25632160 RGD
is active in postsynapse IMP
IMP: Inferred from mutant phenotype
25632160 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
10679783 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
31784514 RGD
located in presynaptic active zone IDA
IDA: Inferred from direct assay
16477614 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ntrk2 Protein Structure

LRR_8

LRR_8: pfam13855 (91 - 149)

TPKR_C2

TPKR_C2: pfam16920 (150 - 194)

Ig

Ig: cl11960 (204 - 282)

Ig

Ig: cd00096 (213 - 217)

Ig

Ig: cd00096 (226 - 229)

Ig

Ig: cd00096 (244 - 251)

Ig

Ig: cd00096 (261 - 267)

Ig

Ig: cd00096 (275 - 278)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (285 - 293)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (285 - 378)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (294 - 297)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (300 - 308)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (311 - 318)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (321 - 324)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (329 - 334)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (340 - 348)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (356 - 364)

IgI_TrkB_d5

IgI_TrkB_d5: cd05855 (367 - 375)

PTKc_TrkB

PTKc_TrkB: cd05093 (546 - 833)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 837 a.a.
Protein Preferred Names Protein Names

BDNF/NT-3 growth factors receptor

  • GP145-TrkB/GP95-TrkB

  • neural receptor protein-tyrosine kinase (trkB)

  • neurotrophic tyrosine kinase, receptor, type 2

  • neurotrophic tyrosine receptor kinase type 2

  • trkB tyrosine kinase

Recombinant Ntrk2 Proteins

Cat. No. Product Name Accession Purity
HY-P73574 TrkB Protein, Rat (HEK293, His, solution) Q63604-2 (C32-H429) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73575 TrkB Protein, Rat (HEK293, Fc) Q63604-2 (C32-H429) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-131003 Taletrectinib Inhibitor 99.63% Unkown

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09631 NTRK2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-131003A Taletrectinib free base Inhibitor / Unkown
HY-101977A (R,S)-Selitrectinib Inhibitor / Unkown
HY-E70870 TRKB(NTRK2) Recombinant Human Active Protein Kinase / Unkown
HY-RS09632 Ntrk2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09633 Ntrk2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991098 Anti-TrkB/NTRK2 Antibody Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ntrk2 NCBI NCBI:4915