Ntrk2 - neurotrophic receptor tyrosine kinase 2 Gene

Rattus norvegicus

Also known as Tkrb; trkB; TRKB1; trk-B; RATTRKB1

Gene ID: 25054 | Gene type: protein coding

About Ntrk2

Primary_assembly 17: 5,559,043-5,869,136 reverse strand.mRatBN7.2:CM026990.1

This gene has 5 transcripts (splice variants), 288 orthologues, 54 paralogues and is associated with 42 phenotypes. Biased expression in Brain (RPKM 177.9), Spleen (RPKM 47.3) and 6 other tissues.

Summary

Enables several functions, including brain-derived neurotrophic factor binding activity; brain-derived neurotrophic factor-activated receptor activity; and protein homodimerization activity. Involved in several processes, including brain-derived neurotrophic factor receptor signaling pathway; positive regulation of cell communication; and regulation of neuron projection development. Acts upstream of or within positive regulation of Glucocorticoid Receptor signaling pathway. Located in several cellular components, including distal axon; perikaryon; and postsynaptic density. Is integral component of plasma membrane. Is active in glutamatergic synapse and postsynapse. Used to study glaucoma. Biomarker of several diseases, including attention deficit hyperactivity disorder; colitis; mental depression; post-traumatic stress disorder; and temporal lobe epilepsy. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; developmental and epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Ntrk2 Products(2)

mRNA	Protein	Name
NM_001163168.3	NP_001156640.1	BDNF/NT-3 growth factors receptor isoform 2 precursor
NM_012731.3	NP_036863.1	BDNF/NT-3 growth factors receptor isoform 1 precursor

Ntrk2 Protein Structure

LRR_8

TPKR_C2

IgI_TrkB_d5

PTKc_TrkB

0
200
400
600
837 a.a.

Protein Preferred Names

Protein Names

BDNF/NT-3 growth factors receptor

GP145-TrkB/GP95-TrkB	neural receptor protein-tyrosine kinase (trkB)
neurotrophic tyrosine kinase, receptor, type 2	neurotrophic tyrosine receptor kinase type 2
trkB tyrosine kinase

Recombinant Ntrk2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73574	TrkB Protein, Rat (HEK293, His)	Q63604-2 (C32-H429)	≥95%
HY-P73575	TrkB Protein, Rat (HEK293, Fc)	Q63604 (M1-H429)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-131003	Taletrectinib	Inhibitor	99.78%	Phase 2
HY-131003A	Taletrectinib free base	Inhibitor	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09631	NTRK2 Human Pre-designed siRNA Set A	/	Unkown
HY-RS09632	Ntrk2 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09633	Ntrk2 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ntrk2	NCBI	NCBI:4915
Canis familiaris	Ntrk2	NCBI	NCBI:484147
Mus musculus	Ntrk2	NCBI	NCBI:18212

Name
Email *

	Sorry, but the email address you supplied was invalid.