St6gal1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Gene

Also Known as Siat1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25197

Summary

Enables Sialyltransferase activity. Involved in several processes, including negative regulation of macrophage apoptotic process; protein sialylation; and regulation of substrate adhesion-dependent cell spreading. Located in Golgi medial cisterna; Golgi trans cisterna; and endoplasmic reticulum. Used to study high grade glioma. Orthologous to human ST6GAL1 (ST6 beta-galactoside alpha-2,6-sialyltransferase 1). [provided by Alliance of Genome Resources, Apr 2022]

St6gal1 Products (2)

mRNA Protein Name
NM_001113344.1 NP_001106815.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform 1
NM_147205.2 NP_671738.2 beta-galactoside alpha-2,6-sialyltransferase 1 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables sialyltransferase activity IDA
IDA: Inferred from direct assay
12626411 RGD
Biological Process GO Annotation Evidence References Source
involved in negative regulation of chemotaxis IDA
IDA: Inferred from direct assay
11559557 RGD
involved in negative regulation of macrophage apoptotic process IDA
IDA: Inferred from direct assay
21930713 RGD
involved in positive regulation of mononuclear cell proliferation IDA
IDA: Inferred from direct assay
21930713 RGD
involved in protein sialylation IDA
IDA: Inferred from direct assay
21930713 RGD
involved in regulation of substrate adhesion-dependent cell spreading IDA
IDA: Inferred from direct assay
11559557 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
9046376 RGD
Cellular Component GO Annotation Evidence References Source
located in Golgi medial cisterna IDA
IDA: Inferred from direct assay
12626411 RGD
located in Golgi trans cisterna IDA
IDA: Inferred from direct assay
12626411 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

beta-galactoside alpha-2,6-sialyltransferase 1

  • CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1

  • ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

  • ST6Gal I

  • ST6GalI

  • Sialyltransferase 1 (beta-galactoside alpha-2,6-sialytransferase)

  • Sialyltransferase 1 (beta-galactoside alph

Recombinant St6gal1 Proteins

Cat. No. Product Name Accession Purity
HY-P76663 ST6GAL1 Protein, Rat (HEK293, His) P13721-1/NP_001106815.1 (K27-C403) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173496 ST6GAL1-IN-1 Inhibitor 99.33% Unkown
HY-163548 SPP-002 Inhibitor 98.0% Unkown
HY-E70148 ST6 Gal Sialyltransferase 1 / Unkown
HY-RS17282 St6gal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172888 SPP-037 Inhibitor / Unkown
HY-179101 IAN-15B Inhibitor / Unkown
HY-RS13852 ST6GAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23737 St6gal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991369 EBU-141 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens St6gal1 NCBI NCBI:6480