ST6GAL1 - ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Gene

Also Known as ST6N; CDw75; SIAT1; ST6GalI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6480

About ST6GAL1

Cytogenetic location: 3q27.3 Genomic coordinates (GRCh38): 3:186,930,526-187,078,553 (from NCBI)

This gene has 24 transcripts (splice variants), 232 orthologues and 14 paralogues. Broad expression in liver (RPKM 87.7), lymph node (RPKM 37.8) and 18 other tissues.

Summary

This gene encodes a member of Glycosyltransferase family 29. The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The protein, which is normally found in the Golgi but can be proteolytically processed to a soluble form, is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6, CD75, and CD76. This gene has been incorrectly referred to as CD75. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]

ST6GAL1 Products (4)

mRNA Protein Name
NM_001353916.2 NP_001340845.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_003032.3 NP_003023.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173216.2 NP_775323.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform a
NM_173217.2 NP_775324.1 beta-galactoside alpha-2,6-sialyltransferase 1 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-galactoside alpha-2,6-sialyltransferase activity IDA
IDA: Inferred from direct assay
23999306 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16237761 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20378551 GOA
enables sialyltransferase activity IDA
IDA: Inferred from direct assay
21081508 GOA
Biological Process GO Annotation Evidence References Source
involved in N-acetylneuraminate metabolic process IDA
IDA: Inferred from direct assay
23999306 GOA
involved in protein N-linked glycosylation via asparagine IDA
IDA: Inferred from direct assay
23999306 GOA
involved in sialylation IDA
IDA: Inferred from direct assay
23999306 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
20378551 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST6GAL1 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (156 - 388)

  • 0
  • 100
  • 200
  • 300
  • 406 a.a.
Protein Preferred Names Protein Names

beta-galactoside alpha-2,6-sialyltransferase 1

  • B-cell antigen CD75

Recombinant ST6GAL1 Proteins

Cat. No. Product Name Accession Purity
HY-P71116 ST6GAL1 Protein, Human (HEK293, His) P15907 (K27-C406) ≥ 95%, as determined by reducing SDS-PAGE.

ST6GAL1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810927 CD75 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Colon Adenocarcinoma

  • Adenocarcinoma Of Colon

  • Adenocarcinoma Of The Colon

  • Colonic Adenocarcinoma
Puerperal Pulmonary Embolism

  • Obstetric Pulmonary Embolism
Swine Influenza

  • Influenza Due To Influenza A Virus Subtype H1n1
Congenital Muscular Dystrophy-Dystroglycanopathy Type A11

  • Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies Type A11

  • Mddga11

  • Walker-Warburg Syndrome Or Muscle-Eye-Brain Disease B3galnt2-Related

  • Congenital Muscular Dystrophy-Dystroglycanopathy With Brain And Eye Anomalies, Type A11
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Congenital Disorder Of Glycosylation, Type In

  • Congenital Disorder Of Glycosylation

  • CDG1N

  • Congenital Disorders Of Glycosylation

  • Cdg In

  • Cdgin

  • Congenital Disorder Of Glycosylation 1n

  • Carbohydrate-Deficient Glycoprotein Syndrome

  • Cdg

  • Rft1-Cdg

  • Cdg-In

  • Congenital Disorder Of Glycosylation Type In

  • Carbohydrate Deficient Glycoprotein Syndrome

  • Cdg Syndrome

  • Congenital Disorder Of Glycosylation In

  • Carbohydrate-Deficient Glycoprotein Syndromes

  • Cdg Syndrome Type In

  • Carbohydrate Deficient Glycoprotein Syndrome Type In

  • Congenital Disorder Of Glycosylation Type 1n

  • Man5glcnac2-Pp-Dol Flippase Deficiency

  • Glycosylation, Congenital Disorder Of

  • Glycosylation, Congenital Disorder Of, Type In
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-173496 ST6GAL1-IN-1 Inhibitor 99.22% Unkown
HY-163548 SPP-002 Inhibitor 98.0% Unkown
HY-RS17282 St6gal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-172888 SPP-037 Inhibitor / Unkown
HY-179101 IAN-15B Inhibitor / Unkown
HY-RS13852 ST6GAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23737 St6gal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991369 EBU-141 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ST6GAL1 MGD MGI:108470
Canis familiaris ST6GAL1 VGNC VGNC:46856
Felis catus ST6GAL1 VGNC VGNC:65726
Bos taurus ST6GAL1 VGNC VGNC:35337
Macaca mulatta ST6GAL1 VGNC VGNC:77823
Rattus norvegicus ST6GAL1 RGD RGD:3676
Others ST6GAL1 NCBI