Lrp2 - LDL receptor related protein 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29216

Summary

Enables several functions, including PDZ domain binding activity; insulin-like growth factor I binding activity; and low-density lipoprotein particle receptor binding activity. Involved in several processes, including endocytic Hemoglobin import into cell; positive regulation of transport; and response to vitamin D. Located in several cellular components, including apical plasma membrane; axonal growth cone; and brush border membrane. Part of receptor complex. Used to study hypertension. Biomarker of autosomal dominant polycystic kidney disease; end stage renal disease; membranous glomerulonephritis; and nephrosis. Human ortholog(s) of this gene implicated in Donnai-Barrow syndrome and autoimmune thyroiditis. Orthologous to human LRP2 (LDL receptor related protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Lrp2 Products (1)

mRNA Protein Name
NM_030827.2 NP_110454.2 low-density lipoprotein receptor-related protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables PDZ domain binding IPI
IPI: Inferred from physical interaction
21325834 RGD
enables hemoglobin binding IDA
IDA: Inferred from direct assay
11805171 RGD
enables hormone binding IPI
IPI: Inferred from physical interaction
15131016 RGD
enables insulin-like growth factor I binding IDA
IDA: Inferred from direct assay
16306401 RGD
enables low-density lipoprotein particle receptor binding IPI
IPI: Inferred from physical interaction
22349218 RGD
enables nuclear receptor binding IPI
IPI: Inferred from physical interaction
16143106 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10769163 RGD
enables protein transporter activity IDA
IDA: Inferred from direct assay
16306401 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
21372499 RGD
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta clearance IMP
IMP: Inferred from mutant phenotype
16306401 RGD
involved in animal organ regeneration IEP
IEP: Inferred from expression pattern
15266031 RGD
involved in cellular response to growth factor stimulus IMP
IMP: Inferred from mutant phenotype
16306401 RGD
involved in chemoattraction of axon IMP
IMP: Inferred from mutant phenotype
26598525 RGD
involved in endocytic hemoglobin import into cell IMP
IMP: Inferred from mutant phenotype
11805171 RGD
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
15670845 RGD
involved in endosomal transport IMP
IMP: Inferred from mutant phenotype
9039057 RGD
involved in metal ion transport IDA
IDA: Inferred from direct assay
15126248 RGD
involved in metanephric proximal tubule development IEP
IEP: Inferred from expression pattern
30645697 RGD
involved in positive regulation of endocytosis IMP
IMP: Inferred from mutant phenotype
10766831 RGD
involved in positive regulation of lipoprotein transport IMP
IMP: Inferred from mutant phenotype
10766831 RGD
involved in protein import IMP
IMP: Inferred from mutant phenotype
16128811 RGD
involved in receptor-mediated endocytosis IDA
IDA: Inferred from direct assay
11595644 RGD
involved in receptor-mediated endocytosis IMP
IMP: Inferred from mutant phenotype
8626514 RGD
involved in response to X-ray IDA
IDA: Inferred from direct assay
12121845 RGD
involved in response to leptin IMP
IMP: Inferred from mutant phenotype
17324488 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
9541123 RGD
involved in response to vitamin D IEP
IEP: Inferred from expression pattern
9541123 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15266031 RGD
involved in transcytosis IMP
IMP: Inferred from mutant phenotype
14657389 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10919857 RGD
located in axonal growth cone IDA
IDA: Inferred from direct assay
26598525 RGD
located in brush border IDA
IDA: Inferred from direct assay
11912251 RGD
located in brush border membrane IDA
IDA: Inferred from direct assay
6752952 RGD
located in cell surface IDA
IDA: Inferred from direct assay
10766831 RGD
located in endosome IDA
IDA: Inferred from direct assay
17063000 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
17063000 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
17324488 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
22349218 RGD
part of receptor complex IDA
IDA: Inferred from direct assay
19202329 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 2

  • LRP-2

  • glycoprotein 330

  • gp330

  • low density lipoprotein-related protein 2

  • megalin

Lrp2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Lrp2 P98158 Dab2 Rattus norvegicus O88797
Anti Bait CoIP
10769163
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS17962 Lrp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24433 Lrp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07797 LRP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrp2 NCBI NCBI:4036