Kcnk3 - potassium two pore domain channel subfamily K member 3 Gene

Also Known as rTASK; Task-1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29553

Summary

Enables open rectifier Potassium Channel activity and protein C-terminus binding activity. Involved in several processes, including cellular response to zinc ion; cochlea development; and negative regulation of cytosolic calcium ion concentration. Located in plasma membrane. Used to study pulmonary venoocclusive disease. Biomarker of status epilepticus. Human ortholog(s) of this gene implicated in primary pulmonary hypertension. Orthologous to human KCNK3 (potassium two pore domain channel subfamily K member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk3 Products (1)

mRNA Protein Name
NM_033376.2 NP_203694.1 potassium channel subfamily K member 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables open rectifier potassium channel activity IDA
IDA: Inferred from direct assay
9437008 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
12437930 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IMP
IMP: Inferred from mutant phenotype
12215606 RGD
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
9437008 RGD
involved in cochlea development IEP
IEP: Inferred from expression pattern
15094499 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
16436472 RGD
involved in positive regulation of voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
31347976 RGD
involved in potassium ion transport IDA
IDA: Inferred from direct assay
15282272 RGD
involved in regulation of resting membrane potential IMP
IMP: Inferred from mutant phenotype
31347976 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
9437008 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
14637154 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium channel subfamily K member 3

  • TWIK-related acid-sensitive K(+) channel 1

  • TWIK-related acid-sensitive K+ channel

  • acid-sensitive potassium channel protein TASK-1

  • potassium channel, subfamily K, member 3

  • potassium channel, two pore domain subfamily K, member 3

  • two pore K(+) channel

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12345 ML365 Inhibitor 99.28% Unkown
HY-RS07159 KCNK3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19452 Kcnk3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25944 Kcnk3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnk3 NCBI NCBI:3777