Alox5ap - arachidonate 5-lipoxygenase activating protein Gene

Rattus norvegicus

Gene ID: 29624 | Gene type: protein coding

About Alox5ap

Primary_assembly 12: 5,748,944-5,772,986 reverse strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 201 orthologues, 3 paralogues and is associated with 23 phenotypes. Biased expression in Lung (RPKM 111.6), Spleen (RPKM 67.3) and 9 other tissues.

Summary

Enables Enzyme binding activity and identical protein binding activity. Contributes to arachidonate 5-lipoxygenase activity. Involved in leukotriene biosynthetic process; Lipoxygenase pathway; and positive regulation of acute inflammatory response. Located in cytosol; endoplasmic reticulum; and nuclear envelope. Used to study pulmonary hypertension. Biomarker of glomerulonephritis. Human ortholog(s) of this gene implicated in several diseases, including asthma; brain infarction (multiple); breast cancer; cerebral palsy; and coronary artery disease (multiple). Orthologous to human ALOX5AP (arachidonate 5-lipoxygenase activating protein). [provided by Alliance of Genome Resources, Apr 2022]

Alox5ap Products(1)

mRNA	Protein	Name
NM_017260.2	NP_058956.1	arachidonate 5-lipoxygenase-activating protein

Alox5ap Protein Structure

MAPEG

0
100
161 a.a.

Protein Preferred Names

Protein Names

arachidonate 5-lipoxygenase-activating protein

5-lipoxygenase-activating protein FLAP	FLAP
MK-886-binding protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS00623	ALOX5AP Human Pre-designed siRNA Set A	/	Unkown
HY-RS00624	Alox5ap Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS00625	Alox5ap Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alox5ap	NCBI	NCBI:241

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