GNS - Gns glucosamine (N-acetyl)-6-sulfatase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 299825

Summary

Enables N-acetylglucosamine-6-sulfatase activity; glycosaminoglycan binding activity; and sulfate binding activity. Involved in keratan sulfate catabolic process. Located in lysosome. Human ortholog(s) of this gene implicated in mucopolysaccharidosis III and mucopolysaccharidosis type IIID. Orthologous to human GNS (glucosamine (N-acetyl)-6-sulfatase). [provided by Alliance of Genome Resources, Apr 2022]

GNS Products (1)

mRNA Protein Name
NM_001011989.1 NP_001011989.1 N-acetylglucosamine-6-sulfatase precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables N-acetylglucosamine-6-sulfatase activity IDA
IDA: Inferred from direct assay
3161730 RGD
enables glycosaminoglycan binding IPI
IPI: Inferred from physical interaction
3161730 RGD
enables sulfate binding IPI
IPI: Inferred from physical interaction
3161730 RGD
Biological Process GO Annotation Evidence References Source
involved in keratan sulfate catabolic process IDA
IDA: Inferred from direct assay
3161730 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

N-acetylglucosamine-6-sulfatase

  • N-acetylglucosamine-6-sulfatase-like

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-109061 Lazertinib 99.87% Unkown

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-137978A Ezurpimtrostat hydrochloride 99.26% Phase 2
HY-137978 Ezurpimtrostat 99.37% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-109061B Lazertinib mesylate 99.85% Unkown
HY-109061A Lazertinib mesylate hydrate / Unkown
HY-183351 GN-604 / Unkown
HY-RS05581 GNS Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19296 Gns Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25787 Gns Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens GNS NCBI NCBI:2799