Havcr2 - hepatitis A virus cellular receptor 2 Gene

Also Known as tim3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 363578

Summary

Predicted to enable metal ion binding activity. Predicted to be involved in several processes, including regulation of cytokine production; regulation of leukocyte activation; and Toll-like Receptor signaling pathway. Located in cell surface. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hepatocellular carcinoma and renal cell carcinoma. Orthologous to human HAVCR2 (hepatitis A virus cellular receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Havcr2 Products (1)

mRNA Protein Name
NM_001100762.1 NP_001094232.1 hepatitis A virus cellular receptor 2 homolog precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
24508263 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hepatitis A virus cellular receptor 2 homolog

  • HAVcr-2

  • T cell immunoglobulin mucin-3

  • T-cell immunoglobulin and mucin domain-containing protein 3

  • T-cell immunoglobulin mucin receptor 3

  • T-cell membrane protein 3

  • TIM-3

  • TIMD-3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (4)
Cat. No. Product Name Effect
Purity Phase
HY-P990085 Verzistobart Inhibitor 99.9% Phase 2
HY-P990701 Lomvastomig 99.9% Phase 2
HY-P991395 TQB2618 Inhibitor 97.51% Phase 2
HY-P991397 Sym023 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147273 Fulimetibant Antagonist 99.60% Unkown
HY-RS06022 HAVCR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17115 Havcr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23560 Havcr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Havcr2 NCBI NCBI:84868