TMIGD1 - transmembrane and immunoglobulin domain containing 1 Gene

Also Known as TMIGD; UNQ9372

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 388364

About TMIGD1

This gene has 2 transcripts (splice variants) and 185 orthologues. Biased expression in small intestine (RPKM 67.8) and colon (RPKM 47.6).

Summary

Involved in several processes, including negative regulation of apoptotic process; regulation of cell migration; and regulation of membrane permeability. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TMIGD1 Products (2)

mRNA Protein Name
NM_001319942.2 NP_001306871.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 2 precursor
NM_206832.3 NP_996663.1 transmembrane and immunoglobulin domain-containing protein 1 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
37542259 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
26342724 GOA
involved in regulation of cell migration IDA
IDA: Inferred from direct assay
26342724 GOA
involved in regulation of cell population proliferation IDA
IDA: Inferred from direct assay
26342724 GOA
involved in regulation of membrane permeability IMP
IMP: Inferred from mutant phenotype
26342724 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26342724 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
26342724 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMIGD1 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (44 - 120)

I-set

I-set: Immunoglobulin I-set domain (131 - 212)

  • 0
  • 100
  • 200
  • 262 a.a.
Protein Preferred Names Protein Names

transmembrane and immunoglobulin domain-containing protein 1

  • AWKS9372

TMIGD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TMIGD1 Q6UXZ0 BANF1 Homo sapiens O75531
Anti Tag CoIP
37542259
Intra
TMIGD1 Q6UXZ0 BANF1 Homo sapiens O75531
Anti Bait CoIP
37542259
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TMIGD1 Proteins

Cat. No. Product Name Accession Purity
HY-P77247 TMIGD1 Protein, Human (HEK293, His) Q6UXZ0-1/NP_996663.1 (V30-P220) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77248 TMIGD1 Protein, Human (HEK293, Fc) Q6UXZ0-1 (V30-P220) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Appendix Disease

  • Disorder Of Appendix
Appendix Cancer

  • Appendiceal Neoplasms

  • Cancer Of The Appendix

  • Malignant Neoplasm Of Appendix Vermiformis

  • Malignant Tumor Of Appendix

  • Malignant Tumor Of The Appendix

  • Malignant Neoplasm Of Appendix

  • Carcinoma Of The Appendix
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14756 TMIGD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18572 Tmigd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25056 Tmigd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus TMIGD1 VGNC VGNC:66376
Mus musculus TMIGD1 MGD MGI:1913851
Canis familiaris TMIGD1 VGNC VGNC:55003
Macaca mulatta TMIGD1 VGNC VGNC:79923
Bos taurus TMIGD1 VGNC VGNC:55877
Rattus norvegicus TMIGD1 RGD RGD:1307444
Others TMIGD1 NCBI