LCN1 - lipocalin 1 Gene

Also Known as TP; TLC; PMFA; VEGP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3933

About LCN1

Cytogenetic location: 9q34.3 Genomic coordinates (GRCh38): 9:135,521,440-135,526,540 (from NCBI)

This gene has 2 transcripts (splice variants), 170 orthologues and 12 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the Lipocalin Family of small secretory proteins. Lipocalins are extracellular transport proteins that bind to a variety of hydrophobic ligands. The encoded protein is the primary lipid binding protein in tears and is overproduced in response to multiple stimuli including Infection and stress. The encoded protein may be a marker for chromosome aneuploidy as well as an autoantigen in Sjogren's syndrome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and two pseudogenes of this gene are also located on the long arm of chromosome 9. [provided by RefSeq, Nov 2011]

LCN1 Products (4)

mRNA	Protein	Name
NM_001252617.2	NP_001239546.1	lipocalin-1 isoform 1 precursor
NM_001252618.2	NP_001239547.1	lipocalin-1 isoform 2 precursor
NM_001252619.2	NP_001239548.1	lipocalin-1 isoform 3 precursor
NM_002297.4	NP_002288.1	lipocalin-1 isoform 1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chloride ion binding	IDA IDA: Inferred from direct assay	15489503	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	11287427	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	15489503	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular space	IDA IDA: Inferred from direct assay	8999869	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LCN1 Protein Structure

Lipocalin

0
100
176 a.a.

Protein Preferred Names	Protein Names
lipocalin-1	VEG protein

LCN1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LCN1	P31025	RECK	Homo sapiens	Q6P9E2	Validated Y2H	32296183
Intra	LCN1	P31025	FAM25C	Homo sapiens	B3EWG5	Y2H Array	32296183
Intra	LCN1	P31025	FAM25C	Homo sapiens	B3EWG5	Y2H Prey Pooling	32296183
Intra	LCN1	P31025	PDYN	Homo sapiens	P01213	Anti Tag CoIP	28514442
Intra	LCN1	P31025	PDYN	Homo sapiens	P01213	Anti Tag CoIP	33961781
Intra	LCN1	P31025	UBQLN2	Homo sapiens	Q9UHD9	Y2H Array	32296183
Intra	LCN1	P31025	UBQLN2	Homo sapiens	Q9UHD9	Y2H Prey Pooling	32296183
Intra	LCN1	P31025	UBQLN2	Homo sapiens	Q9UHD9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LCN1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75905	LCN1/Lipocalin-1 Protein, Human (HEK293, His)	P31025 (H19-D176)	≥ 95%, as determined by reducing SDS-PAGE.

LCN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85259	Lipocalin-1 Antibody (YA4951)	WB, IHC-P, ICC/IF, ELISA	Human

Related Diseases

Diseases	Alias
Lateral Displacement Of Eye	Lateral Displacement Of Globe
Pleurisy
Kwashiorkor	Kwashiokor Nutritional Edema With Dyspigmentation Of Skin And Hair Nutritional Oedema With Dyspigmentation Of Skin And/Or Hair
Ophthalmia Nodosa
Lacrimal Apparatus Disease	Lacrimal Apparatus Diseases
Apperceptive Agnosia
Dry Eye Syndrome	Dry Eye Syndromes Dry Eye Disease Tear Film Insufficiency Xerophthalmia
Filamentary Keratitis
Excessive Tearing	Epiphora Lacrimal Apparatus Diseases Excessive Tear Production Watering Eye
Blepharitis
Cicatricial Entropion
Pulmonary Large Cell Neuroendocrine Carcinoma	Large Cell Lung Neuroendocrine Carcinoma
Conjunctivochalasis
Background Diabetic Retinopathy	Non Proliferative Diabetic Retinopathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy
Eyelid Disease	Eyelid Diseases Eyelid Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07554	LCN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27274	Lcn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LCN1	RGD	RGD:619872
Others	LCN1	NCBI